益生菌或合生制剂能帮助减肥吗
创作:szx 审核:szx 2019年04月07日
  • 纳入19项随机试验(28篇发表的研究、1412名受试者),分析口服益生菌或合生制剂对超重/肥胖成人的影响;
  • 试验中使用的益生菌包括屎肠球菌、嗜热链球菌、乳杆菌属菌株、双歧杆菌属菌株等,合生制剂中使用的益生元包括菊粉、低聚果糖等,干预时长从3周到24周不等;
  • 口服益生菌或合生制剂对平均体重变化、平均BMI变化均无显著影响,但可显著降低受试者的平均腰围。
主编推荐语
szx
Nutrition Reviews上发表的一项荟萃分析结果,对19项随机试验(近1500名受试者)进行分析后发现,口服益生菌或合生制剂无法降低超重/肥胖成人的体重与BMI,仅可显著降低受试者的腰围。
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Effects of oral supplementation with probiotics or synbiotics in overweight and obese adults: a systematic review and meta-analyses of randomized trials

口服益生菌或合生制剂对超重/肥胖成人的影响:一项对随机试验的系统性综述及荟萃分析

10.1093/nutrit/nuz001

2019-03-28, Review

Abstract & Authors:展开

Abstract:收起
Context: Recent evidence suggests that modulation of the gut microbiota may contribute to body weight control.
Objective: This systematic review aimed to assess the effects of oral supplementation with probiotics or synbiotics on body weight, body mass index (BMI), and waist circumference in overweight and obese adults (BMI ≥ 25 kg/m2).
Data Sources: Five electronic databases—PubMed, Embase, Cochrane Library/CENTRAL, LILACS, and Web of Science—were searched from inception to August 2017. No language restrictions were applied.
Study Selection: Randomized and quasi-randomized parallel trials that assessed the effects of oral supplementation with probiotics or synbiotics vs any other intervention but bariatric surgery or fecal transplantation in overweight or obese adults were selected.
Data Extraction: Three teams of 2 authors independently assessed risk of bias and extracted data from the included trials. Data were pooled using inverse-variance random-effects meta-analyses. The quality of evidence was assessed using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system.
Results: Nineteen randomized trials (28 publications, 1412 participants) were included. There were no differences in mean body weight change [mean difference (MD), −0.54 kg; 95%CI, −1.09 to 0.01; I2 = 0%; moderate quality of evidence) or mean BMI change (MD, −0.19 kg/m2; 95%CI, −0.43 to 0.04; I2 = 51%; low quality of evidence) between groups who received probiotics or synbiotics and control groups. Oral supplementation with probiotics or synbiotics reduced mean waist circumference compared with control (MD, −0.82 cm; 95%CI, −1.43 to −0.21; I2 = 46%; low quality of evidence).
Conclusions: The findings suggest that oral supplementation with probiotics or synbiotics has a small effect to reduce waist circumference but no effect on body weight or BMI, although the quality of evidence is low to moderate. Therefore, the current evidence is not definitive. Large-scale trials are needed and may help to better inform clinical practice.

First Authors:
Erica A Suzumura

Correspondence Authors:
Erica A Suzumura

All Authors:
Erica A Suzumura,Angela C Bersch-Ferreira,Camila R Torreglosa,Jacqueline T da Silva,Audrey Y Coqueiro,Marilyn GF Kuntz,Pedro P Chrispim,Bernardete Weber,Alexandre B Cavalcanti

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