汕头大学团队:生命早期环境污染物暴露引起母胎代谢组改变(综述)
创作:Epi汪 审核:Epi汪 2020年06月19日
  • 检索筛选后,最终纳入15篇相关文献,但相互异质性均较大;
  • 重金属、有机污染物、尼古丁、空气污染物等环境污染物暴露对母体尿液和血液代谢组的影响,主要集中在脂类、氨基酸和核酸代谢途径上;
  • 砷、多氯联苯、尼古丁和PM2.5等暴露与脐带代谢产物变化存在关联;
  • 这些代谢物改变主要涉及能量代谢、激素代谢、氧化应激和炎症等方面;
  • 暂无研究关注环境毒物暴露和胎盘代谢的关联;
  • 代谢物改变可能是环境污染物影响母胎健康的重要通路。
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本综述检索了目前有关妊娠期环境污染暴露与母胎血浆、尿液、脐带血等代谢产物变化的关联研究,总结了部分规律,也指出了目前研究存在的问题。值得感兴趣的研究者阅读。
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Early-life exposure to widespread environmental toxicants and maternal-fetal health risk: A focus on metabolomic biomarkers

生命早期暴露于广泛的环境毒物与母胎健康风险的关联:关注代谢组生物标志物

10.1016/j.scitotenv.2020.139626

2020-06-03, Article

Abstract & Authors:展开

Abstract:收起
Prenatal exposure to widespread environmental toxicants is detrimental to maternal health and fetal development. The effects of environmental toxicants on maternal and fetal metabolic profile changes have not yet been summarized. This systematic review aims to summarize the current studies exploring the association between prenatal exposure to environmental toxicants and metabolic profile alterations in mother and fetus. We searched the MEDLINE (PubMed) electronic database for relevant literature conducted up to September 18, 2019 with some key terms. From the initial 155 articles, 15 articles met the inclusion and exclusion criteria, and consist of highly heterogeneous research methods. Seven studies assessed the effects of multiple environmental pollutants (metals, organic pollutants, nicotine, air pollutants) on the maternal urine and blood metabolomic profile; five studies evaluated the effects of arsenic, polychlorinated biphenyls (PCBs), nicotine, and ambient fine particulate matter (PM2.5) on the cord blood metabolomic profile; and one study assessed the effects of smoking exposure on the amniotic fluid metabolomic profile. The alteration of metabolic pathways in these studies mainly involve energy metabolism, hormone metabolism, oxidative stress and inflammation. No population study investigated the association between environmental toxicants and placental metabolomics. This systematic review provides evidence that prenatal exposure to a variety of environmental pollutants can affect maternal and fetal metabolomic characteristics. Integration of environmental toxicant exposure and metabolomics data in maternal-fetal samples is helpful to understand the interaction between toxicants and metabolites, so as to reveal the pathogenesis of fetal disease or diseases of fetal origin.

First Authors:
Yifeng Dai

Correspondence Authors:
Xijin Xu

All Authors:
Yifeng Dai,Xia Huo,Zhiheng Cheng,Marijke M Faas,Xijin Xu

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