专家共识:NAFLD改名MAFLD
创作:orchid 审核:mildbreeze 03月28日
  • 国际专家组建议,以“代谢相关脂肪性肝病( MAFLD)”取代现有命名“非酒精性脂肪性肝病(NAFLD)”;
  • MAFLD的诊断以代谢功能障碍为基础,可与其他肝脏疾病共存,并在疾病进展上存在协同作用;
  • MAFLD具有异质性,成因复杂,由遗传易感性、环境和代谢综合征成分等因素的动态互作形成,根据患者亚表型分层、识别疾病主要驱动因素有助于精准诊疗;
  • 不同类型的创新临床试验设计方案和个性化联合疗法,或能克服疾病异质性带来的临床挑战。
主编推荐语
mildbreeze
非酒精性脂肪性肝病(NAFLD)发病率逐渐上升,人们对疾病的认识愈加深入,其命名与诊断标准却并无更新。旧的命名由于对疾病的驱动因素及其异质性定义并不准确,间接影响了精准诊疗和药物研发。近日,国际脂肪肝专家小组就NAFLD更名为代谢相关脂肪性肝病(MAFLD)一事经投票达成共识并发表于《Gastroenterology》。这篇共识文章重点探讨了更名原因和依据,总结疾病特征并提出临床研究的创新策略,期待更名能为推动临床实践和公共卫生策略产生正面影响。
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Gastroenterology [IF:17.373]

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

MAFLD:一项由共识驱动的代谢相关脂肪性肝病的命名法

10.1053/j.gastro.2019.11.312

02-07, Article

Abstract & Authors:展开

Abstract:收起
Fatty liver associated with metabolic dysfunction is common, affects a quarter of the population, and has no approved drug therapy. While pharmacotherapies are in development, response rates appear modest. The heterogeneous pathogenesis of metabolic fatty liver diseases and inaccuracies in terminology and definitions necessitate a reappraisal of nomenclature to inform clinical trial design and drug development. A group of experts sought to integrate current understanding of patient heterogeneity captured under the acronym nonalcoholic fatty liver disease (NAFLD) and provide suggestions on terminology that more accurately reflects pathogenesis and can help in patient stratification for management. Experts reached consensus that NAFLD does not reflect current knowledge and metabolic (dysfunction) associated fatty liver disease “MAFLD” was suggested as a more appropriate overarching term. This opens the door for efforts from the research community to update the nomenclature and sub-phenotype the disease in order to accelerate the translational path to new treatments.

First Authors:
Mohammed Eslam

Correspondence Authors:
Mohammed Eslam,Arun J Sanyal,Jacob George

All Authors:
Mohammed Eslam,Arun J Sanyal,Jacob George,on behalf of an international consensus panel

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