江南大学陈卫:微量元素+肠道菌群或可作为自闭症的生物标志物
创作:aluba 审核:aluba 2019年02月26日
  • 纳入136名3-7岁的儿童,其中78名自闭症谱系障碍(ASD)患儿及58名健康儿童;
  • 收集分析头发样本中的铅、镉、砷、铜、锌、铁、汞、钙及镁元素的水平,并分析粪便菌群组成;
  • ASD患儿头发中铅、砷、铜、锌、汞、钙及镁元素的水平显著升高,肠道菌群中9个菌属的相对丰度升高;
  • 砷及汞元素的水平与肠道中的Parabacteroides及颤螺旋菌属显著相关;
  • 利用金属元素及菌群标志物构建诊断ASD的随机森林模型,准确率可达84.00%。
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aluba
来自江南大学陈卫团队在Environmental Research上发表的一项最新研究,发现自闭症谱系障碍(ASD)患儿的肠道菌群组成发生变化,并伴随着头发中几种微量金属元素的含量变化。
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Disturbance of trace element and gut microbiota profiles as indicators of autism spectrum disorder: A pilot study of Chinese children

微量元素及肠道菌群谱的破坏可作为自闭症谱系障碍的指示器:一项在中国儿童中的先导性研究

10.1016/j.envres.2019.01.060

2019-02-05, Article

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Autism spectrum disorder (ASD) is a neuro-developmental disorder that is characterized by impairments of reciprocal social interaction and restricted stereotyped repetitive behavior. The goal of the present study was to investigate the trace element and gut microbiota profiles of Chinese autistic children and screen out potential metallic or microbial indicators of the disease. One hundred and thirty-six children (78 with ASD and 58 healthy controls) aged from 3 to 7 years were enrolled. The levels of lead, cadmium, arsenic, copper, zinc, iron, mercury, calcium and magnesium in hair samples from the children were analyzed. Fecal samples were also collected and the children's gut microbiota profiles were characterized by 16s rRNA sequencing. Concentrations of lead, arsenic, copper, zinc, mercury, calcium and magnesium were significantly higher in the ASD group than in the control group. Linear discriminant analysis effect size analysis indicated that the relative abundance of nine genera was increased in the autistic children. Redundancy analysis showed that arsenic and mercury were significantly associated with Parabacteroides and Oscillospira in the gut. A random forest model was trained with high accuracy (84.00%) and the metallic and microbial biomarkers of ASD were established. Our results indicate significant alterations in the trace element and gut microbiota profiles of Chinese children with ASD and reveal the potential pathogenesis of this disease in terms of metal metabolism and gut microecology.

First Authors:
Qixiao Zhai

Correspondence Authors:
Wei Chen

All Authors:
Qixiao Zhai,Shi Cen,Jinchi Jiang,Jianxin Zhao,Hao Zhang,Wei Chen

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