Nature Reviews:肠道脂代谢与疾病(综述)
创作:迟卉 审核:潇洒小姐陈 03月01日
  • 膳食脂类在肠上皮细胞摄取和酯化,经内质网包装和高尔基体转运分泌到淋巴系统;
  • 缺乏参与脂代谢的蛋白和酶会导致以脂类和脂溶性维生素吸收缺陷为特征的疾病,如无β脂蛋白血症和乳糜微粒贮积病;
  • 上皮细胞胞质中的脂滴可动态储存三酰甘油,并多维度参与脂质代谢;
  • 针对如肠腔脂肪酶、胆汁酸和NPC1L1、MGAT2、DGAT1和MTP等与吸收过程相关的蛋白及分子的药物可治疗饮食引起的肥胖症及其并发症;
  • 小肠肠道菌群可调节宿主代谢和膳食脂类。
主编推荐语
潇洒小姐陈
人体脂类主要包括脂肪(如三酸甘油)、磷脂和类固醇(如胆固醇),其中膳食脂类的主要包括为三酸甘油、酯化胆固醇和磷脂。本文介绍了膳食脂类的消化、吸收、胞内再合成及最终排入淋巴系统的过程,也介绍了人体中脂类的归处,如可组成高密度脂蛋白、低密度脂蛋白和胞内脂滴或进行脂肪酸氧化。最后作者提到了近期小鼠实验发现了肠道菌群在脂质代谢中起调节左右,但仍需进一步探索至特定菌种甚至是菌株。
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Regulation of intestinal lipid metabolism: current concepts and relevance to disease

肠道脂质代谢的调节:当前概念和与疾病的关系

10.1038/s41575-019-0250-7

02-03, Review

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Abstract:收起
Lipids entering the gastrointestinal tract include dietary lipids (triacylglycerols, cholesteryl esters and phospholipids) and endogenous lipids from bile (phospholipids and cholesterol) and from shed intestinal epithelial cells (enterocytes). Here, we comprehensively review the digestion, uptake and intracellular re-synthesis of intestinal lipids as well as their packaging into pre-chylomicrons in the endoplasmic reticulum, their modification in the Golgi apparatus and the exocytosis of the chylomicrons into the lamina propria and subsequently to lymph. We also discuss other fates of intestinal lipids, including intestinal HDL and VLDL secretion, cytosolic lipid droplets and fatty acid oxidation. In addition, we highlight the applicability of these findings to human disease and the development of therapeutics targeting lipid metabolism. Finally, we explore the emerging role of the gut microbiota in modulating intestinal lipid metabolism and outline key questions for future research.

First Authors:
Chih- Wei Ko

Correspondence Authors:
Patrick Tso

All Authors:
Chih- Wei Ko,Jie Qu,Dennis D Black,Patrick Tso

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