Akk菌或可改善脂肪肝炎相关的认知功能障碍
创作:菌菌君 审核:szx 03月17日
  • EE(可诱导运动刺激及感觉认知的增强)及AKK可逆转HFHC饮食诱导的大鼠认知功能障碍(包括空间工作记忆和新物体识别障碍),而而LGG无此作用;
  • AKK与EE的作用机制不同:AKK可恢复大脑代谢活性(逆转HFHC饮食诱导的细胞色素c氧化酶活性降低),而EE可导致大脑代谢活性的降低;
  • AKK和LGG仅会引起肠道菌群组成和多样性的轻微改变,不会造成菌群的显著改变,而EE可导致厚壁菌门和疣微菌门的增加。
主编推荐语
szx
高脂高胆固醇(HFHC)饮食通常用于诱导早期非酒精性脂肪性肝炎(NASH)模型。Gut Microbes上发表的一项最新研究,发现环境强化(EE)或应用Akk菌CIP107961(AKK)可逆转HFHC饮食诱导的大鼠认知功能障碍,而鼠李糖乳杆菌GG(LGG)无此作用。机制上,AKK通过增强大脑代谢活性,而EE通过降低大脑代谢活性并改变肠道菌群组成而发挥作用。该研究结果提示,AKK或可用于治疗NASH相关的认知功能障碍。
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Gut Microbes [IF:7.74]

Akkermansia muciniphila and environmental enrichment reverse cognitive impairment associated with high-fat high-cholesterol consumption in rats

Akk菌和丰富环境可逆转高脂高胆固醇摄入相关的大鼠认知障碍

10.1080/19490976.2021.1880240

03-08, Article

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Abstract:收起
Nonalcoholic steatohepatitis (NASH) is one of the most prevalent diseases globally. A high-fat, high-cholesterol (HFHC) diet leads to an early NASH model. It has been suggested that gut microbiota mediates the effects of diet through the microbiota–gut–brain axis, modifying the host’s brain metabolism and disrupting cognition. Here, we target NASH-induced cognitive damage by testing the impact of environmental enrichment (EE) and the administration of either Lacticaseibacillus rhamnosus GG (LGG) or Akkermansia muciniphila CIP107961 (AKK). EE and AKK, but not LGG, reverse the HFHC-induced cognitive dysfunction, including impaired spatial working memory and novel object recognition; however, whereas AKK restores brain metabolism, EE results in an overall decrease. Moreover, AKK and LGG did not induce major rearrangements in the intestinal microbiota, with only slight changes in bacterial composition and diversity, whereas EE led to an increase in Firmicutes and Verrucomicrobia members. Our findings illustrate the interplay between gut microbiota, the host’s brain energy metabolism, and cognition. In addition, the findings suggest intervention strategies, such as the administration of AKK, for the management of the cognitive dysfunction related to NASH.

First Authors:
Sara G Higarza

Correspondence Authors:
Miguel Gueimonde,Natalia Arias

All Authors:
Sara G Higarza,Silvia Arboleya,Jorge L Arias,Miguel Gueimonde,Natalia Arias

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