姜长涛团队:靶向肠道菌群及其代谢产物——代谢疾病治疗的新趋势(综述)
创作:Vera 审核:Vera 2020年12月25日
  • 肠道菌群紊乱存在于很多代谢性疾病中,如肥胖、非酒精性脂肪肝、心脑血管疾病以及多囊卵巢综合症;
  • 宿主基因、免疫及饮食都塑造着肠道菌群,同时,肠道菌群的代谢产物与免疫应答也影响着宿主的健康;
  • 二甲双胍可通过降低脆弱拟杆菌丰度,增加甘氨熊脱氧胆酸水平,并抑制FXR信号通路从而抑制肝糖原合成,缓解高血糖症;
  • 因此,靶向肠道菌群及其代谢产物或可成为治疗代谢性疾病的有效疗法。
主编推荐语
Vera
代谢性疾病(如肥胖,PCOS,NAFLD,高血糖症)和肠道微生物密切相关,宿主的基因、饮食、免疫时时刻刻塑造着菌群,菌群也通过其代谢产物与宿主进行互作,进而影响宿主的健康。北京大学的姜长涛团队在Protein & Cell上发表的综述,总结了近年来研究较多的代谢性疾病中发挥作用的菌群代谢产物,为未来靶向菌群及代谢产物的治疗策略提供了重要的借鉴。
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Protein & Cell [IF:10.164]

The role of the gut microbiome and its metabolites in metabolic diseases

肠道菌群及其代谢产物在代谢性疾病中的作用

10.1007/s13238-020-00814-7

2020-12-21, Review

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It is well known that an unhealthy lifestyle is a major risk factor for metabolic diseases, while in recent years, accumulating evidence has demonstrated that the gut microbiome and its metabolites also play a crucial role in the onset and development of many metabolic diseases, including obesity, type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular disease and so on. Numerous microorganisms dwell in the gastrointestinal tract, which is a key interface for energy acquisition and can metabolize dietary nutrients into many bioactive substances, thus acting as a link between the gut microbiome and its host. The gut microbiome is shaped by host genetics, immune responses and dietary factors. The metabolic and immune potential of the gut microbiome determines its significance in host health and diseases. Therefore, targeting the gut microbiome and relevant metabolic pathways would be effective therapeutic treatments for many metabolic diseases in the near future. This review will summarize information about the role of the gut microbiome in organism metabolism and the relationship between gut microbiome-derived metabolites and the pathogenesis of many metabolic diseases. Furthermore, recent advances in improving metabolic diseases by regulating the gut microbiome will be discussed.

First Authors:
Jiayu Wu

Correspondence Authors:
Changtao Jiang

All Authors:
Jiayu Wu,Kai Wang,Xuemei Wang,Yanli Pang,Changtao Jiang

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