港大团队:幽门螺旋杆菌根除治疗与老年人较低的胃癌发病率相关
创作:szx 审核:szx 2018年05月11日
  • 收集2003-2012年间接受幽门螺旋杆菌(Hp)根除治疗的患者的随访记录,分析Hp根除治疗对胃癌发病率的影响;
  • 共分析73237名接受过Hp根除治疗的患者,200人(0.27%)在随访期间患上胃癌;
  • 在60岁以上的老年人中,相比于未接受过Hp根除治疗的群体,接受过Hp根除治疗的群体的胃癌发病率显著降低;
  • 但对于更年轻的群体,两组间的胃癌发病率无显著差异;
  • 接受Hp根治治疗10年以上之后,40岁以上的群体的胃癌发病率显著降低。
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szx
来自香港大学团队的研究,分析了超过70000名接受过幽门螺旋杆菌根除治疗的患者,发现在中老年人中,接受过根除治疗与胃癌发病率风险降低相关。
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Gastroenterology [IF:17.373]

Effects of Helicobacter PYLORI Treatment on Incidence of Gastric Cancer in Older Individuals

幽门螺旋杆菌根除治疗对老年人胃癌发病率的影响

10.1053/j.gastro.2018.03.028

2018-03-14, Article

Abstract & Authors:展开

Abstract:收起
BACKGROUND & AIMS: Although eradication of Helicobacter pylori infection reduces the risk of gastric cancer, few data are available on its effects in older subjects. We compared the age-specific risk of gastric cancer in a large cohort of subjects who received H pylori eradication therapy vs a matched general population.
METHODS: We searched the Hospital Authority database of Hong Kong to identify individuals with H pylori infection who had received a course of clarithromycin-containing eradication therapy from January 2003 through December 2012. We compared the gastric cancer incidence in this cohort with the expected incidence for the local general population by retrieving the gastric cancer incidence of the age- and sex-matched population from 2003 through 2014 (the latest available year) from the Hong Kong Cancer Registry. The primary outcome was the incidence of gastric cancer development in the cohort treated for H pylori infection vs the expected number of gastric cancer cases in the general population. Analyses were conducted by a priori age groups of less than 40 years, 40-59 years, and 60 years or older.
RESULTS: Among 73,237 subjects infected with H pylori who received eradication therapy, 200 (0.27%) developed gastric cancer during a median follow-up time of 7.6 years. Compared with the matched general population, the gastric cancer risk was significantly lower in subjects 60 years or older who had received H pylori treatment (standardized incidence ratio [SIR], 0.82; 95% CI, 0.69-0.97; P=.02) but not in younger groups. When data were stratified based on time from H pylori treatment (less than 5 years, 5-9 years, and 10 or more years), the risk of gastric cancer was significantly lower than the general population 10 or more years after eradication in the group 40-59 years old (SI, 0.32; 95% CI 0.08-0.88; P=.04) and the group 60 years or older (SIR, 0.42; 95% CI 0.42-0.84; p = 0.02) than the other age groups.
CONCLUSIONS: In an analysis of data from a public hospital database on Hong Kong, we associated treatment of H pylori infection with a lower risk of gastric cancer, particularly in older subjects, 10 or more years after treatment.

First Authors:
Wai K Leung

Correspondence Authors:
Wai K Leung

All Authors:
Wai K Leung,Irene O L Wong,Ka Shing Cheung,Kar Fu Yeung,Esther W Chan,Angel Y S Wong,Lijia Chen,Ian C K Wong,David Y Graham

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