JFB:褐藻多糖,或是潜在益生元(综述)
  • 重点介绍褐藻多糖(BSP,主要为岩藻多糖、海带多糖和藻酸盐)的结构和化学性质、提取方法,益生元作用和免疫活性及其机制;
  • 体内、体外实验中,BSP不被消化酶降解,可作为肠道菌群的碳源促进有益菌群生长;
  • BSP通过调节肠道菌群、产生短链脂肪酸、直接与免疫细胞toll样受体作用和产生粘蛋白增强免疫应答;
  • 未来需要更多的临床研究和基础研究验证BSP的益生元作用和免疫调节活性,奠定其作为新型益生元的应用前景的理论基础。
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蓝灿辉 | 热心肠先生
这是一篇系统性介绍褐藻多糖的综述文章,对其作为益生元的潜力进行深入分析,很值得一读。特别推荐!
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Prospects of brown seaweed polysaccharides (BSP) as prebiotics and potential immunomodulators

褐藻多糖作为益生元和潜在的免疫调节剂的前景

10.1111/jfbc.12392

2017-07-18, Review

Abstract & Authors:展开

Abstract:收起
Prebiotics enhance immune response through the modulation of intestinal microbial activities, production of short chain fatty acids (SCFA), direct interaction with toll-like receptors and mucin production. These non-digestible food components are known to be resistant to enzymatic hydrolysis by digestive enzymes and are utilized as carbon source for the growth of beneficial bacteria population through the process of fermentation. Brown seaweed polysaccharides (BSP) have been described as emerging prebiotics due to their potential to stimulate gut microbiota activities at in vitro and in vivo stages. This review therefore examines evidence of the relationship between the prebiotic capacity of BSP, their structure, extraction, and possible mechanisms of immunomodulation.

First Authors:
Chigozie Louis Okolie

Correspondence Authors:
Beth Mason

All Authors:
Chigozie Louis Okolie, Subin R C K Rajendran, Chibuike C Udenigwe, Alberta N A Aryee, Beth Mason

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