TI:怎样的小鼠模型,能真正反映人的免疫响应?(综述)
  • 在人的一生中,会经历各种各样急性和慢性病原体感染,病原体驱动的选择会塑造人体免疫系统;
  • 而用于生物医学研究的实验室小鼠在良好卫生条件下繁育,且免于暴露在特定病原体中;
  • 本文总结一些近期研究,表明病原体感染对激活基本的免疫水平和免疫系统功能非常重要;
  • 充分考虑人类和小鼠的病原体暴露的重要性,对改进针对人类疾病的小鼠模型的质量具有很大的潜在作用。
主编推荐语
蓝灿辉 | 热心肠先生
关于如何确保小鼠模型更能反映人类免疫和其他生理状态的文献有一些,这篇最近发表在Trends in Immunology上的综述,很值得认真看看。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片

Making Mouse Models That Reflect Human Immune Responses

创造能反映人类免疫响应的小鼠模型

10.1016/j.it.2016.12.007

2017-02-01, Review

Abstract & Authors:展开

Abstract:收起
Humans are infected with a variety of acute and chronic pathogens over the course of their lives, and pathogen-driven selection has shaped the immune system of humans. The same is likely true for mice. However, laboratory mice we use for most biomedical studies are bred in ultra-hygienic environments, and are kept free of specific pathogens. We review recent studies that indicate that pathogen infections are important for the basal level of activation and the function of the immune system. Consideration of these environmental exposures of both humans and mice can potentially improve mouse models of human disease.

First Authors:
Lili Tao

Correspondence Authors:
Tiffany A Reese

All Authors:
Lili Tao,Tiffany A Reese

评论