Abstract & Authors:展开
Phagocytes, including neutrophils and macrophages, have been suggested to function in a cooperative way in the initial phase of inflammatory responses, but their interaction and integration in the resolution of inflammation and tissue repair remain unclear. Here we show that neutrophils have crucial functions in liver repair by promoting the phenotypic conversion of pro-inflammatory Ly6CCXCR1 monocytes/macrophages to pro-resolving Ly6CCXCR1 macrophages. Intriguingly, reactive oxygen species (ROS), expressed predominantly by neutrophils, are important mediators that trigger this phenotypic conversion to promote liver repair. Moreover, this conversion is prevented by the depletion of neutrophils via anti-Ly6G antibody, genetic deficiency of granulocyte colony-stimulating factor, or genetic deficiency of NADPH oxidase 2 (Nox2). By contrast, adoptive transfer of WT rather than Nox2 neutrophils rescues the impaired phenotypic conversion of macrophages in neutrophil-depleted mice. Our findings thus identify an intricate cooperation between neutrophils and macrophages that orchestrate resolution of inflammation and tissue repair.
Wenting Yang,Yuandong Tao
Fuchu He,Li Tang
Wenting Yang,Yuandong Tao,Yan Wu,Xinyuan Zhao,Weijie Ye,Dianyuan Zhao,Ling Fu,Caiping Tian,Jing Yang,Fuchu He,Li Tang