解放军疾控中心:乳果糖缓解高盐饮食引起的高血压
创作:大力 审核:szx 2019年03月25日
  • 干预4周后,高盐饲料(HSD)增加了Alistipes和Ruminococcaceae_UCG_009的相对丰度,降低乳杆菌属的相对丰度;
  • HSD中添加乳果糖,增加了双歧杆菌属、Alloprevotella和Subdoligranulum的相对丰度;
  • 代谢产物分析显示,乳果糖增加了菌群ATP转运以及色氨酸代谢功能;
  • 乳果糖可改善血清糖脂代谢,显著降低小肠中IL-17a和IL-22的mRNA水平及血清中IL-17a和IL-22水平,缓解便秘,增加粪便钠排泄,降低肠道通透性,维持健康的肠道微环境。
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来自解放军疾控中心的团队在《Molecular Nutrition and Food Research》上发表的一项最新研究,发现乳果糖可调节高盐饮食小鼠的肠道菌群,并改善代谢、降低肠道通透性、抑制肠道炎症,以缓解高盐饮食引起的高血压。
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Targeting the Gut Microbiota to Investigate the Mechanism of Lactulose in Negating the Effects of a High-Salt Diet on Hypertension

以肠道菌群为研究对象,探讨乳果糖抑制高盐饮食对高血压的作用的机制

10.1002/mnfr.201800941

2019-03-02, Article

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SCOPE: High-salt diets (HSDs) are widely considered to cause health problems such as gut microecological imbalances, constipation, and hypertension. This study explored how lactulose as a safe molecule can stimulate bodily responses to alleviate salt-sensitive hypertension by regulating the gut microbiotas of HSD-fed mice.
METHODS AND RESULTS: After 4 weeks, the blood pressures of mice fed a high-salt plus lactulose diet (HSLD) were significantly lower than those of the HSD-fed mice. The HSD increased the abundances of Alistipes and Ruminococcaceae_UCG_009 and reduced the abundance of Lactobacillus in the gut, while lactulose supplementation increased the abundances of Bifidobacterium, Alloprevotella, and Subdoligranulum. Fecal metabolic profiling showed significant increases in metabolites involved in ATP-binding cassette transporters pathways, and tryptophan metabolism was significantly reduced in the HSLD group compared with the HSD group. Lactulose maintained the intestinal microenvironmental health in the HSD-fed mice by improving glycolipid metabolism, decreasing the small intestinal IL-17a and IL-22 mRNA levels and serum IL-17a and IL-22 levels, relieving constipation, increasing fecal sodium, and reducing intestinal permeability.
CONCLUSION: Lactulose negates salt-sensitive hypertension. Regulating the gut microbiota is a potential treatment for salt-sensitive hypertension. This article is protected by copyright. All rights reserved.

First Authors:
Zheng Zhang,Jiangtao Zhao

Correspondence Authors:
Jing Yuan,Xiangna Zhao

All Authors:
Zheng Zhang,Jiangtao Zhao,Changyu Tian,Xiao Chen,Huan Li,Xiao Wei,Weishi Lin,Naxin Zheng,Aimin Jiang,Ruo Feng,Jing Yuan,Xiangna Zhao

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