Abstract & Authors:展开
SCOPE: High-salt diets (HSDs) are widely considered to cause health problems such as gut microecological imbalances, constipation, and hypertension. This study explored how lactulose as a safe molecule can stimulate bodily responses to alleviate salt-sensitive hypertension by regulating the gut microbiotas of HSD-fed mice.
METHODS AND RESULTS: After 4 weeks, the blood pressures of mice fed a high-salt plus lactulose diet (HSLD) were significantly lower than those of the HSD-fed mice. The HSD increased the abundances of Alistipes and Ruminococcaceae_UCG_009 and reduced the abundance of Lactobacillus in the gut, while lactulose supplementation increased the abundances of Bifidobacterium, Alloprevotella, and Subdoligranulum. Fecal metabolic profiling showed significant increases in metabolites involved in ATP-binding cassette transporters pathways, and tryptophan metabolism was significantly reduced in the HSLD group compared with the HSD group. Lactulose maintained the intestinal microenvironmental health in the HSD-fed mice by improving glycolipid metabolism, decreasing the small intestinal IL-17a and IL-22 mRNA levels and serum IL-17a and IL-22 levels, relieving constipation, increasing fecal sodium, and reducing intestinal permeability.
CONCLUSION: Lactulose negates salt-sensitive hypertension. Regulating the gut microbiota is a potential treatment for salt-sensitive hypertension. This article is protected by copyright. All rights reserved.
Zheng Zhang,Jiangtao Zhao
Jing Yuan,Xiangna Zhao
Zheng Zhang,Jiangtao Zhao,Changyu Tian,Xiao Chen,Huan Li,Xiao Wei,Weishi Lin,Naxin Zheng,Aimin Jiang,Ruo Feng,Jing Yuan,Xiangna Zhao