饮食、肥胖与癌症(综述)
创作:Lexi 审核:Lexi 2020年10月18日
  • 连接肥胖和癌症结果的潜在机制包括:药代动力学、炎症、激素、代谢燃料、微生物组、协变量(如基因多态性、社会经济地位、饮食)、癌症代谢等;
  • 肥胖影响许多特定器官,使之易于癌症发展和/或限制癌症治疗;
  • 许多癌症与恶病质有关,恶病质相关的体重减轻通常被认为是较差的预后标志;
  • 糖皮质激素有增脂作用,高剂量糖皮质激素治疗的癌症与肥胖的增加有关;
  • 癌症患者最常见的饮食干预包括禁食、卡路里限制、限制碳水化合物/生酮饮食等。
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Lexi
最新发表在Annual Review of Nutrition的综述讨论了肥胖、饮食和癌症之间的联系,探索饮食改善癌症结果的潜在机制,包括通过激素、代谢和免疫/炎症效应等途径。饮食干预可以提高癌症患者化疗疗效、降低毒性,并降低长期并发症的风险。因此,了解和扩展这一重要但复杂的辅助癌症治疗策略的科学性是很重要的。
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The Role of Diet in Cancer Prevention and Chemotherapy Efficacy

饮食在癌症预防和化疗疗效中的作用

10.1146/annurev-nutr-013120-041149

2020-06-16, Review

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Despite great advances in treatment, cancer remains a leading cause of death worldwide. Diet can greatly impact health, while caloric restriction and fasting have putative benefits for disease prevention and longevity. Strong epidemiological associations exist between obesity and cancer, whereas healthy diets can reduce cancer risk. However, less is known about how diet might impact cancer once it has been diagnosed and particularly how diet can impact cancer treatment. In the present review, we discuss the links between obesity, diet, and cancer. We explore potential mechanisms by which diet can improve cancer outcomes, including through hormonal, metabolic, and immune/inflammatory effects, and present the limited clinical research that has been published in this arena. Though data are sparse, diet intervention may reduce toxicity, improve chemotherapy efficacy, and lower the risk of long-term complications in cancer patients. Thus, it is important that we understand and expand the science of this important but complex adjunctive cancer treatment strategy.

First Authors:
Steven D Mittelman

Correspondence Authors:
Steven D Mittelman

All Authors:
Steven D Mittelman

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