菌群-肠-脑轴如何调节肠道和大脑(综述)
创作:徐硕 审核:迟卉 03月01日
  • 肠道菌群可通过内分泌(皮质醇),免疫(细胞因子)和神经(迷走,肠神经系统和脊神经)多种途径调控大脑,从而构建微生物-肠-脑(MGB)轴;
  • 肠道细菌产生的短链脂肪酸(SCFA)可刺激肠内5-羟色胺(5-HT)的合成和分泌,5-HT结合其受体后,起到调节运动性、干预神经元发育分化、通过神经信号调控情绪等作用;
  • 通过MGB轴治疗脑肠道疾病的研究证据有限,目前IBS和其他MGB互作障碍的有效疗法仍是个性化饮食联合行为疗法及有限的药物。
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迟卉
精神疾病常与胃肠疾病共病,肠道菌群与大脑之间的通讯也一直是研究热点。Gastroenterology发表综述重点介绍了菌群-肠-脑(MGB)轴在调节肠道和中枢神经系统功能中的作用,以及胃肠运动障碍和情绪障碍等疾病之间的互相影响,总结在这些疾病中出现重叠的生物学结构,并特别强调了神经递质5-羟色胺在胃肠道和大脑中的关键作用。文章慎重指出,尽管相关研究显示出MGB在治疗人脑疾病中的巨大潜力,但将研究中的发现转化为对患者的诊疗方法目前仍尚未成功,关于神经精神疾病的生物疗法仍处于起步阶段。该领域在不同性别种族之间的差异等方面仍存在很大的研究空白有待填充,值得相关科研人员关注。
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Gastroenterology [IF:17.373]

The Microbiota-Gut-Brain Axis: From Motility to Mood

菌群-肠-脑轴:从动力到情绪

10.1053/j.gastro.2020.10.066

01-22, Review

Abstract & Authors:展开

Abstract:收起
The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and extrinsic factors influence signaling along this axis, modulating the function of both the enteric and central nervous systems. More recently the role of the microbiome as an important factor in modulating gut-brain signaling has emerged and the concept of a microbiota-gut-brain axis has been established. In this review, we highlight the role of this axis in modulating enteric and central nervous system function and how this may impact disorders such as Irritable Bowel Syndrome and disorders of mood and affect. We examine the overlapping biological constructs that underpin these disorders with a special emphasis on the neurotransmitter serotonin, which plays a key role in both the gastrointestinal tract and in the brain. Overall, it is clear that although animal studies have shown much promise, more progress is necessary before these findings can be translated for diagnostic and therapeutic benefit in patient populations.

First Authors:
Kara G Margolis

Correspondence Authors:
Kara G Margolis

All Authors:
Kara G Margolis,John F Cryan,Emeran A Mayer

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