吃什么脂肪会影响健康?百万人数据再添新证
创作:兵兵 审核:兵兵 2020年05月10日
  • 美国前瞻性队列2.4万人随访12年的数据显示,膳食总脂肪、多不饱和脂肪(PUFA)的摄入与全因死亡率呈负相关,饱和脂肪(SFA)的摄入与死亡率增加有关;
  • 对29项前瞻性研究(约115万人)的荟萃分析发现:总脂肪、单不饱和脂肪酸(MUFA)和PUFA与全因死亡率呈显著负相关;
  • 总脂肪、MUFA和PUFA与心血管疾病、冠心病死亡并不相关,但SFA与冠心病死亡率显著相关;
  • MUFA和PUFA与中风死亡率呈负相关;
  • 膳食脂肪类型或与重要健康结果相关。
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兵兵
文章结合了前瞻性队列研究与前瞻性研究的荟萃分析,探究不同的膳食脂肪种类与全因、病因特异性死亡率的关系。研究结果显示:总膳食脂肪、MUFA和PUFA与全因死亡率相关,但与心血管疾病、冠心病死亡并不相关;而SFA摄入与冠心病显著相关。因此,膳食脂肪的数量和质量均对健康产生影响。
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Association of types of dietary fats and all-cause and cause-specific mortality: A prospective cohort study and meta-analysis of prospective studies with 1,148,117 participants

膳食脂肪的类别与全因、病因特异性死亡率的关系:对约114.8万人群的前瞻性队列研究与前瞻性研究的荟萃分析

10.1016/j.clnu.2020.03.028

2020-04-03, Article

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Background: Associations between dietary fats and mortality are unclear.
Methods: We evaluated the relationship between quartiles of total fat, mono-unsaturated (MUFA), polyunsaturated (PUFA) and saturated fatty acid (SFA) consumption, and all-cause, coronary heart disease (CHD), stroke, and type 2 diabetes (T2D)-associated mortality in 24,144 participants from the National Health and Nutrition Examination Surveys (NHANES) 1999–2010. We added our results to a meta-analysis based on searches until November 2018.
Results: In fully adjusted Cox-proportional hazard models in our prospective study, there was an inverse association between total fat (HR: 0.90, 95% confidence interval 0.82, 0.99, Q4 vs Q1) and PUFA (0.81, 0.78–0.84) consumption and all-cause mortality, whereas SFA were associated with the increased mortality (1.08, 1.04–1.11). In the meta-analysis of 29 prospective cohorts (n = 1,148,117) we found a significant inverse association between total fat (0.89, 0.82–0.97), MUFA (0.93, 0.87–0.99) and PUFA (0.86, 0.80–0.93) consumption and all-cause mortality. No association was observed between total fat and CVD (0.92, 0.79–1.08) or CHD mortality (1.03 0.99–1.09). A significant association between SFA intake and CHD mortality (1.10, 1.01–1.20) was observed. Neither MUFA nor PUFA were associated with CVD or CHD mortality. Inverse associations were observed between MUFA (0.80, 0.67–0.96) and PUFA (0.84, 0.80–0.90) intakes and stroke mortality.
Conclusions: We showed differential associations of total fat, MUFA and PUFA with all-cause mortality, but not CVD or CHD mortalities. SFA was associated with higher all-cause mortality in NHANES and with CHD mortality in our meta-analysis. The type of fat intake appears to be associated with important health outcomes.

First Authors:
Mohsen Mazidi

Correspondence Authors:
Mohsen Mazidi,Maciej Banach

All Authors:
Mohsen Mazidi,Dimitri P Mikhailidis,Naveed Sattar,Peter P Toth,Suzanne Judd,Michael J Blaha,Adrian V Hernandez,Peter E Penson,Maciej Banach,on behalf of the International Lipid Expert Panel (ILEP) & Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group

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