晚餐不要吃太晚,损伤代谢促肥胖
创作:szx 审核:szx 06月21日
  • 20名健康志愿者(男女各半,平均26岁)随机先后在正常时间(18点)及夜晚(22点)摄入等热量晚餐(分别为RD组及LD组),睡眠时间固定为23点至第二天7点;
  • 相比于RD组,LD组受试者餐后4h内的血糖AUC升高,餐后4h的胰岛素水平升高,甘油三酯达峰时间延缓,游离脂肪酸及膳食脂肪酸氧化降低;
  • LD对睡眠结构无显著影响,但可导致睡眠期间血浆皮质醇水平的增加;
  • LD对男性及女性的代谢影响无显著差异,对习惯早睡者的影响更显著。
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szx
夜晚的卡路里摄入与肥胖及代谢综合征相关。Journal of Clinical Endocrinology and Metabolism上发表的一项随机交叉试验结果,对比20名健康年轻人在正常时间及夜晚时间摄入晚餐后的代谢变化,发现相比于晚上6点吃晚餐,晚上10点吃晚餐可导致血糖、胰岛素的升高,延缓甘油三酯达峰时间,并抑制脂肪酸氧化,这些影响可能促进肥胖的发生。另外,晚吃晚餐对习惯早睡者的代谢影响更大。该研究结果提示,吃晚餐时间不宜太晚,长期晚吃晚餐可能增加肥胖风险。
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Metabolic Effects of Late Dinner in Healthy Volunteers – A Randomized Crossover Clinical Trial

晚吃晚餐对健康志愿者的代谢影响:一项随机交叉临床试验

10.1210/clinem/dgaa354

06-11, Article

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Context: Consuming calories later in the day is associated with obesity and metabolic syndrome. We hypothesized that eating a late dinner alters substrate metabolism during sleep in a manner that promotes obesity.
Objective: To examine the impact of late dinner on nocturnal metabolism in healthy volunteers.
Design and Setting: This is a randomized crossover trial of late dinner (LD, 22:00) versus routine dinner (RD, 18:00), with a fixed sleep period (23:00-07:00) in a laboratory setting.
Participants: 20 healthy volunteers (10 males, 10 females), aged 26.0 ± 0.6 years, BMI 23.2 ± 0.7 kg/m2, accustomed to a bedtime between 22:00-01:00.
Interventions: An isocaloric macronutrient diet was administered on both visits. Dinner (35% daily kcal, 50% carbohydrate, 35% fat) with an oral lipid tracer ([2H31] palmitate, 15 mg/kg) was given at 18:00 on RD and 22:00 on LD.
Main Outcome Measures: Nocturnal and next-morning hourly plasma glucose, insulin, triglycerides, free fatty acids (FFAs), cortisol, dietary fatty acid oxidation, and overnight polysomnography.
Results: LD caused a 4-hour shift in the postprandial period, overlapping with the sleep phase. Independent of this shift, the postprandial period following LD was characterized by higher glucose, a triglyceride peak delay, and lower FFA and dietary fatty acid oxidation. LD did not affect sleep architecture, but increased plasma cortisol. These metabolic changes were most pronounced in habitual earlier sleepers determined by actigraphy monitoring.
Conclusion: LD induces nocturnal glucose intolerance, and reduces fatty acid oxidation and mobilization, particularly in earlier sleepers. These effects might promote obesity if they recur chronically.

First Authors:
Chenjuan Gu

Correspondence Authors:
Jonathan C Jun

All Authors:
Chenjuan Gu,Nga Brereton,Amy Schweitzer,Matthew Cotter,Daisy Duan,Elisabet Børsheim,Robert R Wolfe,Luu V Pham,Vsevolod Y Polotsky,Jonathan C Jun

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