生酮饮食或可改善阿尔兹海默症?
创作:szx 审核:szx 03月02日
  • 21名AD患者随机分别摄入改良生酮饮食或正常饮食(遵循低脂健康饮食指南),干预期12周,中间间隔10周的清洗期;
  • 与正常饮食相比,生酮饮食可显著增加AD患者的ADCS-ADL评分及QOL-AD评分,并非显著地增加ACE-III评分,三种量表分别反映AD患者的日常生活能力、生活质量及认知功能;
  • 另外,生酮饮食还可导致AD患者的心血管风险因素发生有益变化,且未发生严重不良事件。
主编推荐语
szx
阿尔兹海默症(AD)患者的大脑能量代谢受损,生酮饮食可能缓解。Alzheimer's Research and Therapy上发表的一项随机交叉试验结果,对21名AD患者进行12周的生酮饮食或正常饮食干预,发现生酮饮食可显著改善AD患者的日常生活能力及生活质量。
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Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease

改良生酮饮食用于阿尔兹海默症的随机交叉试验

10.1186/s13195-021-00783-x

02-23, Article

Abstract & Authors:展开

Abstract:收起
Background: Brain energy metabolism is impaired in Alzheimer’s disease (AD), which may be mitigated by a ketogenic diet. We conducted a randomized crossover trial to determine whether a 12-week modified ketogenic diet improved cognition, daily function, or quality of life in a hospital clinic of AD patients.
Methods: We randomly assigned patients with clinically confirmed diagnoses of AD to a modified ketogenic diet or usual diet supplemented with low-fat healthy-eating guidelines and enrolled them in a single-phase, assessor-blinded, two-period crossover trial (two 12-week treatment periods, separated by a 10-week washout period). Primary outcomes were mean within-individual changes in the Addenbrookes Cognitive Examination - III (ACE-III) scale, AD Cooperative Study - Activities of Daily Living (ADCS-ADL) inventory, and Quality of Life in AD (QOL-AD) questionnaire over 12 weeks. Secondary outcomes considered changes in cardiovascular risk factors and adverse effects.
Results: We randomized 26 patients, of whom 21 (81%) completed the ketogenic diet; only one withdrawal was attributed to the ketogenic diet. While on the ketogenic diet, patients achieved sustained physiological ketosis (12-week mean beta-hydroxybutyrate level: 0.95 ± 0.34 mmol/L). Compared with usual diet, patients on the ketogenic diet increased their mean within-individual ADCS-ADL (+ 3.13 ± 5.01 points, P = 0.0067) and QOL-AD (+ 3.37 ± 6.86 points, P = 0.023) scores; the ACE-III also increased, but not significantly (+ 2.12 ± 8.70 points, P = 0.24). Changes in cardiovascular risk factors were mostly favourable, and adverse effects were mild.
Conclusions: This is the first randomized trial to investigate the impact of a ketogenic diet in patients with uniform diagnoses of AD. High rates of retention, adherence, and safety appear to be achievable in applying a 12-week modified ketogenic diet to AD patients. Compared with a usual diet supplemented with low-fat healthy-eating guidelines, patients on the ketogenic diet improved in daily function and quality of life, two factors of great importance to people living with dementia.

First Authors:
Matthew C L Phillips

Correspondence Authors:
Matthew C L Phillips

All Authors:
Matthew C L Phillips,Laura M Deprez,Grace M N Mortimer,Deborah K J Murtagh,Stacey McCoy,Ruth Mylchreest,Linda J Gilbertson,Karen M Clark,Patricia V Simpson,Eileen J McManus,Jee-Eun Oh,Satish Yadavaraj,Vanessa M King,Avinesh Pillai,Beatriz Romero-Ferrando,Martijn Brinkhuis,Bronwyn M Copeland,Shah Samad,Shenyang Liao,Jan A C Schepel

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