自闭症谱系障碍婴儿睡眠质量与大脑发育存在关联
创作:尹小甜 审核:Epi汪 2020年05月29日
  • 纳入432名婴儿,分别在6、12、24个月进行核磁共振收集大脑发育数据,通过ISOP量表评估婴儿睡眠质量(得分越高,反映入睡困难,睡眠质量低);
  • 有ASD危险因素且诊断为ASD的婴儿,ISOP得分较高,而有ASD危险因素但未患ASD的婴儿ISOP得分未增高;
  • 患ASD的婴儿,其海马体的发育轨迹与ISOP评分存在关联,而未患ASD的婴儿,无论其是否有高危因素,二者均无关联;
  • ISOP评分与其他大脑皮质结构发育(杏仁核、尾状核等)发育轨迹无关。
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Epi汪
本文通过队列研究,发现在自闭症儿童中,睡眠质量评分与海马体发育轨迹存在关联。且生命早期睡眠质量或与未来患自闭症的风险也存在一定关联。本研究为自闭症儿童神经发育研究提供新的思路。
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Sleep Onset Problems and Subcortical Development in Infants Later Diagnosed With Autism Spectrum Disorder

在随后诊断为自闭症谱系障碍的婴儿睡眠问题与脑皮质发育的关联

10.1176/appi.ajp.2019.19060666

2020-05-07, Article

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OBJECTIVE: Sleep patterns in children with autism spectrum disorder (ASD) appear to diverge from typical development in the second or third year of life. Little is known, however, about the occurrence of sleep problems in infants who later develop ASD and possible effects on early brain development. In a longitudinal neuroimaging study of infants at familial high or low risk for ASD, parent-reported sleep onset problems were examined in relation to subcortical brain volumes in the first 2 years of life.
METHODS: A total of 432 infants were included across three study groups: infants at high risk who developed ASD (N=71), infants at high risk who did not develop ASD (N=234), and infants at low risk (N=127). Sleep onset problem scores (derived from an infant temperament measure) were evaluated in relation to longitudinal high-resolution T1 and T2 structural imaging data acquired at 6, 12, and 24 months of age.
RESULTS: Sleep onset problems were more common at 6-12 months among infants who later developed ASD. Infant sleep onset problems were related to hippocampal volume trajectories from 6 to 24 months only for infants at high risk who developed ASD. Brain-sleep relationships were specific to the hippocampus; no significant relationships were found with volume trajectories of other subcortical structures examined (the amygdala, caudate, globus pallidus, putamen, and thalamus).
CONCLUSIONS: These findings provide initial evidence that sleep onset problems in the first year of life precede ASD diagnosis and are associated with altered neurodevelopmental trajectories in infants at high familial risk who go on to develop ASD. If replicated, these findings could provide new insights into a potential role of sleep difficulties in the development of ASD.

First Authors:
Katherine E MacDuffie

Correspondence Authors:
Katherine E MacDuffie

All Authors:
Katherine E MacDuffie,Mark D Shen,Stephen R Dager,Martin A Styner,Sun Hyung Kim,Sarah Paterson,Juhi Pandey,Tanya St John,Jed T Elison,Jason J Wolff,Meghan R Swanson,Kelly N Botteron,Lonnie Zwaigenbaum,Joseph Piven,Annette M Estes

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