肠道菌群为代谢综合征治疗提供机遇(综述)
  • 代谢综合征是机体内在因素(比如基因和肠道菌群)以及外在因素(比如膳食和生活方式)共同作用的结果;
  • 肠道菌群参与影响机体的肥胖、血脂异常等代谢性疾病;
  • 其与机体代谢的相互作用受多重因素影响,包括肠道屏障损伤、胆汁酸代谢、抗生素使用以及菌群代谢产物;
  • 粪菌移植是研究菌群与代谢相关症状的最直接手段之一;
  • 由于膳食或者生活方式带来的肠道菌群的变化,其造成的影响始于但远不止于肠道;
  • 肠道菌群为代谢综合征治疗提供了机遇。
主编推荐语
兵兵
文章结合现有研究结果,依次从代谢综合征特点、肠道菌群史源、菌群与机体肥胖、菌群代谢物与血脂异常、菌群胰岛素抵抗以及粪菌移植等方面综述了肠道菌群与机体代谢的相互作用。截止到目前的研究结果显示,肠道菌群对机体造成的影响始于但远不止于肠道。
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The gut microbiome and metabolic syndrome

肠道菌群与代谢综合征

10.1172/JCI129194

2019-10-01, Review

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The metabolic syndrome (MetS) is a constellation of risk factors that, if left untreated, will often progress to greater metabolic defects such as type 2 diabetes and nonalcoholic fatty liver disease. While these risk factors have been established for over 40 years, the definition of MetS warrants reconsideration in light of the substantial data that have emerged from studies of the gut microbiome. In this Review we present the existing recent literature that supports the gut microbiome's potential influence on the various risk factors of MetS. The interplay of the intestinal microbiota with host metabolism has been shown to be mediated by a myriad of factors, including a defective gut barrier, bile acid metabolism, antibiotic use, and the pleiotropic effects of microbially produced metabolites. These data show that events that start in the gut, often in response to external cues such as diet and circadian disruption, have far-reaching effects beyond the gut.

First Authors:
Kruttika Dabke

Correspondence Authors:
Kruttika Dabke

All Authors:
Kruttika Dabke,Gustaf Hendrick,Suzanne Devkota

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