合生制剂酸奶或能缓解NAFLD患者的脂肪肝
创作:szx 审核:szx 2018年06月30日
  • 在一项为期24周的非盲随机对照临床试验中,102名非酒精性脂肪性肝病(NAFLD)患者随机分为3组;
  • 2个干预组每日分别摄入300g合生制剂酸奶(动物双歧杆菌+菊粉)或300g的传统酸奶;
  • 相比于传统酸奶干预组及对照组,合生制剂组干预患者的超声检查下的NAFLD分级显著降低;
  • 另外,合生制剂组干预患者血清中的丙氨酸转氨酶、天冬氨酸转氨酶、碱性磷酸酶、γ-谷氨酰转移酶水平显著低于另外2组。
主编推荐语
szx
Journal of Nutrition上发表的一项非盲随机对照临床试验的结果,发现每日摄入300克含有合生制剂(动物双歧杆菌+菊粉)的酸奶,可显著缓解NAFLD患者的脂肪肝,并降低血清中的转氨酶浓度。
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Daily Consumption of Synbiotic Yogurt Decreases Liver Steatosis in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial

每日摄入合生制剂酸奶缓解非酒精性脂肪性肝病患者的脂肪肝:一项随机对照临床试验

10.1093/jn/nxy088

2018-06-20, Article

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Background: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in developed and developing countries. The use of synbiotics has been proposed as a probable management strategy for patients with NAFLD.
Objective: We investigated the effects of synbiotic yogurt on hepatic steatosis and liver enzymes as primary outcomes and on oxidative stress markers, adipokine concentration, and gut peptide concentration as secondary outcomes in patients with NAFLD.
Methods: In this 24-wk, open-label, randomized controlled clinical trial, 102 patients [50 men and 52 women; mean age: 40 y; body mass index (in kg/m2) (mean ± SD): 31.2 ± 4.9] were randomly assigned to 3 groups, including 2 intervention groups and 1 control group. The intervention groups consumed 300 g synbiotic yogurt containing 108 colony-forming units Bifidobacterium animalis/mL and 1.5 g inulin or conventional yogurt daily and were advised to follow a healthy lifestyle (i.e., diet and exercise). The control group was advised to follow a healthy lifestyle alone. We evaluated differences between groups in liver function measures by using repeated-measures ANOVA, ANCOVA, and logistic regression.
Results: At the end of the study, the grades of NAFLD, as determined by ultrasonography, showed a significant decrease in the synbiotic group compared with the conventional and control groups (P < 0.001). The following significant mean ± SD decreases were seen in the synbiotic, conventional, and control groups, respectively: serum concentration of alanine aminotransferase (-14.5 ± 15.6 compared with 4.6 ± 15.4 and 3.1 ± 14.4 IU/L; P = 0.008), aspartate aminotransferase (-7.5 ± 6.1 compared with 3.0 ± 8.2 and 3.1 ± 5.7 IU/L; P < 0.001), alkaline phosphatase (-26.2 ± 16.8 compared with 3.4 ± 30.1 and 1.5 ± 31.9 IU/L; P = 0.024), and γ-glutamyltransferase (-6.0 ± 6.0 compared with 1.0 ± 6.4 and 7.6 ± 11.4 IU/L; P < 0.001).
Conclusion: Synbiotic yogurt consumption improved hepatic steatosis and liver enzyme concentrations in patients with NAFLD. This trial was registered at the Iranian Registry of Clinical Trials website (www.irct.ir) as IRCT2017020932417N2.

First Authors:
Farnush Bakhshimoghaddam

Correspondence Authors:
Mohammad Alizadeh

All Authors:
Farnush Bakhshimoghaddam,Kamran Shateri,Morad Sina,Maryam Hashemian,Mohammad Alizadeh

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