益生元能否改善胖子的抑郁和焦虑相关标志物?
创作:药农 审核:mildbreeze 2019年09月26日
  • 纳入13项随机对照试验,采用系统评价和荟萃分析方法,研究在超重或肥胖成年人中,补充益生元或合生制剂对肥胖、抑郁和焦虑血液生物标志物的影响;
  • 1项研究评估了瘦素(表明补充低聚果糖可降低瘦素水平),4项研究评估了胃饥饿素,10项研究评估了CRP(C-反应蛋白),没有研究评估ACTH、皮质醇、TSH、PTH、维生素D和BDNF;
  • 对于8项研究的荟萃分析显示,补充菊粉型果聚糖益生元,有助于降低超重或肥胖个体的血清胃饥饿素和CRP浓度。
主编推荐语
mildbreeze
肥胖与焦虑和抑郁存在显著关联,与肠道菌群和内分泌变化有关。Nutrition Reviews近期发表一项研究,通过对随机对照试验进行系统综述和荟萃分析,综合评估了益生元/合生制剂干预对肥胖/超重成年人的多种肥胖、抑郁和焦虑血液标志物的作用,表明菊粉型果聚糖或能降低胃饥饿素和C-反应蛋白的水平。
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Prebiotics may reduce serum concentrations of C-reactive protein and ghrelin in overweight and obese adults: a systematic review and meta-analysis

益生元可降低超重和肥胖成人血清C反应蛋白和胃饥饿素的浓度:系统评价和meta分析

10.1093/nutrit/nuz045

2019-09-05, Article

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Context: Biochemical markers correlate positively with the development and severity of obesity, depression, and anxiety, and can be modulated by changes in intestinal microbiota composition.
Objective: A systematic review and meta-analysis was conducted to determine the effects of prebiotics or synbiotics on blood biomarkers of obesity, depression, and anxiety (including: ACTH [adrenocorticotropic hormone], cortisol, leptin, ghrelin, TSH [thyroid-stimulating hormone], PTH [parathyroid hormone], vitamin D, BDNF [brain-derived neurotrophic factor], and PCR [polymerase chain reaction]) in individuals with overweight or obesity.
Data Sources: MEDLINE, Web of Science, Scopus, and CENTRAL databases were searched, along with the reference lists of included articles. Authors were contacted for unpublished data.
Study Selection: RCT in individuals with overweight or obesity, supplemented with prebiotics or synbiotics, assessing any of the outcomes of interest.
Data Extraction: Data were extracted independently by three researchers.
Results: Thirteen studies were identified up to March 7, 2018. Regarding outcomes, 1 study assessed leptin, 4 studies assessed ghrelin, and 10 studies assessed CRP (C-reactive protein). Meta-analysis showed reduction in serum concentrations of ghrelin (−37.17 pg/mL; 95%CI = −69.62, −4.73; P = 0.025) and CRP (SMD [standardized mean difference] = −0.31; 95%CI = −0.58, −0.04; P = 0.027) after supplementation of inulin-type fructans.
Conclusions: Prebiotics may help regulate blood concentrations of ghrelin and CRP in overweight or obese individuals.

First Authors:
Dayanne da Silva Borges

Correspondence Authors:
Dayanne da Silva Borges

All Authors:
Dayanne da Silva Borges,Ricardo Fernandes,Arthur Thives Mello,Ethiene da Silva Fontoura,Adair Roberto Soares dos Santos,Erasmo Benicio Santos de Moraes Trindade

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