创作:szx 审核:szx 2017年07月23日
  • 分析摄入低剂量或中等剂量木糖醇对小鼠的肠道菌群及脂质代谢的影响;
  • 木糖醇显著改变了小鼠粪便菌群的组成,中等剂量的木糖醇降低高脂饮食及正常饮食的小鼠的粪便拟杆菌门及Barnesiella菌属的丰度;
  • 中等剂量的木糖醇增加高脂饮食小鼠的厚壁菌门及普氏菌属的丰度;
  • 身体成分、肝脏及血清中的脂质参数、口服葡萄糖耐受性、肠腔代谢物不受木糖醇的影响。
蓝灿辉 | 热心肠先生
Nutrients [IF:4.546]

Effects of Consuming Xylitol on Gut Microbiota and Lipid Metabolism in Mice



2017-07-14, Article

Abstract & Authors:展开

The sugar alcohol xylitol inhibits the growth of some bacterial species including Streptococcus mutans. It is used as a food additive to prevent caries. We previously showed that 1.5-4.0 g/kg body weight/day xylitol as part of a high-fat diet (HFD) improved lipid metabolism in rats. However, the effects of lower daily doses of dietary xylitol on gut microbiota and lipid metabolism are unclear. We examined the effect of 40 and 200 mg/kg body weight/day xylitol intake on gut microbiota and lipid metabolism in mice. Bacterial compositions were characterized by denaturing gradient gel electrophoresis and targeted real-time PCR. Luminal metabolites were determined by capillary electrophoresis electrospray ionization time-of-flight mass spectrometry. Plasma lipid parameters and glucose tolerance were examined. Dietary supplementation with low- or medium-dose xylitol (40 or 194 mg/kg body weight/day, respectively) significantly altered the fecal microbiota composition in mice. Relative to mice not fed xylitol, the addition of medium-dose xylitol to a regular and HFD in experimental mice reduced the abundance of fecal Bacteroidetes phylum and the genus Barnesiella, whereas the abundance of Firmicutes phylum and the genus Prevotella was increased in mice fed an HFD with medium-dose dietary xylitol. Body composition, hepatic and serum lipid parameters, oral glucose tolerance, and luminal metabolites were unaffected by xylitol consumption. In mice, 40 and 194 mg/kg body weight/day xylitol in the diet induced gradual changes in gut microbiota but not in lipid metabolism.

First Authors:
Takashi Uebanso

Correspondence Authors:
Takashi Uebanso

All Authors:
Takashi Uebanso,Saki Kano,Ayumi Yoshimoto,Chisato Naito,Takaaki Shimohata,Kazuaki Mawatari,Akira Takahashi