庾庆华团队:罗伊氏乳杆菌维持肠道上皮再生,促进粘膜损伤修复
创作:szx 审核:szx 03月12日
  • 罗伊氏乳杆菌D8可增加R-spondin的表达并激活Wnt/β-连环蛋白信号通路,以促进肠道上皮的增殖;
  • 另外,罗伊氏乳杆菌D8可通过维持Wnt/β-连环蛋白信号的活化,以修复TNF诱导的肠道上皮损伤;
  • 在小鼠体内及肠道干细胞中,罗伊氏乳杆菌D8可增加抗菌肽表达,并通过激活Wnt/β-连环蛋白信号以诱导肠道干细胞向潘氏细胞的分化,从而抑制鼠柠檬酸杆菌感染;
  • 罗伊氏乳杆菌D8可维持Lgr5+ 肠道干细胞的数量,并降低肠道中的促炎因子分泌。
主编推荐语
szx
菌群对肠道干细胞的增殖及再生的调控研究较少。来自南京农业大学的庾庆华团队在Gut Microbes上发表的一项最新研究,报道了罗伊氏乳杆菌可通过激活Wnt/β-连环蛋白信号通路,以维持肠道干细胞的数量,并促进肠道上皮的增殖,从而促进肠道上皮损伤后的修复,并增强肠道上皮屏障功能抑制致病菌感染。
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Gut Microbes [IF:7.74]

Lactobacillus reuteri maintains intestinal epithelial regeneration and repairs damaged intestinal mucosa

罗伊氏乳杆菌维持肠道上皮再生并修复损伤的肠道粘膜

10.1080/19490976.2020.1734423

03-05, Article

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Little is known about the regulatory effect of microbiota on the proliferation and regeneration of ISCs. Here, we found that L. reuteri stimulated the proliferation of intestinal epithelia by increasing the expression of R-spondins and thus activating the Wnt/β-catenin pathway. The proliferation-stimulating effect of Lactobacillus on repair is further enhanced under TNF -induced intestinal mucosal damage, and the number of Lgr5+ cells is maintained. Moreover, compared to the effects of C. rodentium on the induction of intestinal inflammation and crypt hyperplasia in mice, L. reuteri protected the intestinal mucosal barrier integrity by moderately modulating the Wnt/β-catenin signaling pathway to avoid overactivation. L. reuteri had the ability to maintain the number of Lgr5+ cells and stimulate intestinal epithelial proliferation to repair epithelial damage and reduce proinflammatory cytokine secretion in the intestine and the LPS concentration in serum. Moreover, activation of the Wnt/β-catenin pathway also induced differentiation toward Paneth cells and increased antimicrobial peptide expression to inhibit C. rodentium colonization. The protective effect of Lactobacillus against C. rodentium infection disappeared upon application of the Wnt antagonist Wnt-C59 in both mice and intestinal organoids. This study demonstrates that Lactobacillus is effective at maintaining intestinal epithelial regeneration and homeostasis as well as at repairing intestinal damage after pathological injury and is thus a promising alternative therapeutic method for intestinal inflammation.

First Authors:
Haiqin Wu,Shuang Xie

Correspondence Authors:
Qinghua Yu

All Authors:
Haiqin Wu,Shuang Xie,Jinfeng Miao,Yuchen Li,Zhihua Wang,Minjuan Wang,Qinghua Yu

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