ISME:柔嫩梭菌群改善小鼠的肝脏健康并减少脂肪组织炎症
创作:szx 审核:szx 2017年06月25日
  • 研究口服柔嫩梭菌群对高脂饮食小鼠的影响;
  • 与高脂饮食对照小鼠相比,高脂饮食+口服柔嫩梭菌群的小鼠肝脏脂肪含量、天冬氨酸转氨酶及丙氨酸转氨酶降低,肝脏内脂肪酸氧化及脂联素信号增强;
  • 柔嫩梭菌群可降低小鼠肝脏中的几种三酰基甘油、磷脂、胆固醇酯;
  • 内脏脂肪组织中脂联素表达上调,皮下及内脏脂肪组织对胰岛素敏感性增加且炎症减少;
  • 柔嫩梭菌群增加肌肉质量,与线粒体呼吸增强、肠道菌群组成改变及肠道完整性增加相关。
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ISME Journal [IF:9.18]

Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice

柔嫩梭菌群改善高脂饮食小鼠的肝脏健康并减少脂肪组织炎症

10.1038/ismej.2017.24

2017-04-04, Article

Abstract & Authors:展开

Abstract:收起
Faecalibacterium prausnitzii is considered as one of the most important bacterial indicators of a healthy gut. We studied the effects of oral F. prausnitzii treatment on high-fat fed mice. Compared to the high-fat control mice, F. prausnitzii-treated mice had lower hepatic fat content, aspartate aminotransferase and alanine aminotransferase, and increased fatty acid oxidation and adiponectin signaling in liver. Hepatic lipidomic analyses revealed decreases in several species of triacylglycerols, phospholipids and cholesteryl esters. Adiponectin expression was increased in the visceral adipose tissue, and the subcutaneous and visceral adipose tissues were more insulin sensitive and less inflamed in F. prausnitzii-treated mice. Further, F. prausnitzii treatment increased muscle mass that may be linked to enhanced mitochondrial respiration, modified gut microbiota composition and improved intestinal integrity. Our findings show that F. prausnitzii treatment improves hepatic health, and decreases adipose tissue inflammation in mice and warrant the need for further studies to discover its therapeutic potential.

First Authors:
Eveliina Munukka,Anniina Rintala

Correspondence Authors:
Satu Pekkala

All Authors:
Eveliina Munukka,Anniina Rintala,Raine Toivonen,Matts Nylund,Baoru Yang,Anna Takanen,Arno Hänninen,Jaana Vuopio,Pentti Huovinen,Sirpa Jalkanen,Satu Pekkala

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