Nature子刊:可抑制肠道肿瘤的产短链脂肪酸菌
创作:szx 审核:szx 03月01日
  • 在结直肠癌小鼠模型肿瘤发生的早期阶段,小肠及结肠中的Faecalibaculum rodentium丰度显著降低;
  • 分离出该菌的菌株F. PB1,发现在结直肠癌小鼠模型的肠道环境中,粘液组成变化抑制了F. PB1的定殖;
  • F. PB1可通过释放短链脂肪酸,在不影响适应性免疫细胞的情况下抑制肿瘤细胞生长;
  • 其它能够生产短链脂肪酸的细菌也可发挥F. PB1的抗肿瘤作用,鉴定出在人体内与F. PB1对应的细菌为Holdemanella biformis。
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szx
Nature Microbiology上发表的一项最新研究,在结直肠癌小鼠模型中发现Faecalibaculum rodentium可通过产生短链脂肪酸发挥抗肿瘤作用,而在人体内与其对应的细菌为Holdemanella biformis,在晚期腺瘤阶段丰度降低,并可通过释放短链脂肪酸在体外抑制肿瘤细胞系或患者肿瘤样本的生长。
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Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth

小鼠内源性菌群成员Faecalibaculum rodentium及其在人体中的同源物抑制肠道肿瘤生长

10.1038/s41564-019-0649-5

01-27, Article

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The microbiota has been shown to promote intestinal tumourigenesis, but a possible anti-tumourigenic effect has also been postulated. Here, we demonstrate that changes in the microbiota and mucus composition are concomitant with tumourigenesis. We identified two anti-tumourigenic strains of the microbiota—Faecalibaculum rodentium and its human homologue, Holdemanella biformis—that are strongly under-represented during tumourigenesis. Reconstitution of ApcMin/+ or azoxymethane- and dextran sulfate sodium-treated mice with an isolate of F. rodentium (F. PB1) or its metabolic products reduced tumour growth. Both F. PB1 and H. biformis produced short-chain fatty acids that contributed to control protein acetylation and tumour cell proliferation by inhibiting calcineurin and NFATc3 activation in mouse and human settings. We have thus identified endogenous anti-tumourigenic bacterial strains with strong diagnostic, therapeutic and translational potential.

First Authors:
Elena Zagato

Correspondence Authors:
Maria Rescigno

All Authors:
Elena Zagato,Chiara Pozzi,Alice Bertocchi,Tiziana Schioppa,Fabiana Saccheri,Silvia Guglietta,Bruno Fosso,Laura Melocchi,Giulia Nizzoli,Jacopo Troisi,Marinella Marzano,Bianca Oresta,Ilaria Spadoni,Koji Atarashi,Sara Carloni,Stefania Arioli,Giulia Fornasa,Francesco Asnicar,Nicola Segata,Simone Guglielmetti,Kenya Honda,Graziano Pesole,William Vermi,Giuseppe Penna,Maria Rescigno

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2020-02-17

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2020-02-28

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