胎盘脂肪代谢或是造成自然流产的因素
创作:兵兵 审核:兵兵 2018年04月01日
  • 对比自然流产与人为流产发现,自然流产女性蜕膜和绒毛组织中的总C18:3n-3,蜕膜组织中总n-3多不饱和脂肪酸,绒毛组织中的总C18:2n-6都显著较低。
  • 同时,自然流产女性绒毛组织中的C20:4n-6/C20:5n-3比例显著较高,但是前列腺素 I2和羟基二十碳五烯酸、白三烯B5及凝血恶烷B3都显著低于正常组。
  • 此外,蜕膜和绒毛组织中较低的溶血磷脂,以及绒毛组织中较低的甘油二酯也与自然流产有关。
  • 以上都有可能是造成中国女性自然流产的潜在因素。
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Food and Function [IF:5.396]

Association of fatty acids and lipids metabolism in placenta with early spontaneous pregnancy loss in Chinese women

胎盘中的脂肪酸和脂质代谢与中国女性早期自然流产的关系

10.1039/c7fo01545c

2018-01-25, Article

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The aim of the present study was to evaluate the association of fatty acids and lipids metabolism in placenta with early spontaneous pregnancy loss (ESPL) in Chinese women. Seventy women with ESPL and 29 healthy pregnant women who asked for legal induced abortion were included in the case and control groups, respectively. The gestational age of the subject foetuses in both the case and control groups ranged from 4 to 10 weeks. The total fatty acids composition in the decidual and villous tissues was detected by gas-liquid chromatography using a standard method. Metabonomics analysis of the decidual and villous tissues was conducted by ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOFMS). The total C18:3n-3 in the decidual and villous tissues, total n-3 polyunsaturated fatty acid (n-3 PUFA) in the decidual tissue, and total C18:2n-6 in the villous tissue were all significantly lower in the case group than in the control group. The ratio of C20:4n-6/C20:5n-3 in villous tissue was significantly higher, but prostaglandin I2 as well as hydroxyeicosapentaenoic acid, leukotriene B5 and thromboxane B3 in the villous tissue were significantly lower in the case group than in the control group. In addition, the low content of lysophosphatide in the decidual and villous tissues and the low content of diacylglycerol in the villous tissue were also associated with the occurance of ESPL. In conclusion, the lack of essential fatty acids, high ratio of C20:4n-6/C20:5n-3, abnormal eicosanoids metabolism and low content of lysophosphatide and diacylglycerol in the placenta were all potential risk factors for ESPL in Chinese.

First Authors:
Kelei Li,Xiaotian Zhang

Correspondence Authors:
Xiaoying Zheng,Duo Li

All Authors:
Kelei Li,Xiaotian Zhang,Gong Chen,Lijun Pei,Hailong Xiao,Jiajing Jiang,Jiaomei Li,Xiaoying Zheng,Duo Li

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