补充特定益生菌和合生制剂对超重人士菌群和代谢的影响
  • 一项双盲随机对照试验中,超重受试者分4组,补充安慰剂、聚葡萄糖(LU)、动物双歧杆菌乳亚种420(B420)、LU+B420,干预6个月;
  • 干预结束时B420组的乳杆菌属和Akk菌属增多,LU+B420组的Akk菌属、Christensenellaceae(与肥胖情况负相关)和甲烷短杆菌属增多,Paraprevotella减少;
  • 与安慰剂组相比,LU+B420组中,血清初级胆汁酸GCA和次级胆汁酸GUDCA、THDCA+TUDCA水平降低,菌群功能宏基因组中代谢通路改变。
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mildbreeze
Beneficial Microbes近期发表的一项研究,对芬兰开展的一项临床试验中134名超重受试者的数据进行分析,表明补充动物双歧杆菌乳亚种420及其与聚葡萄糖的合生制剂,可影响受试者的肠道菌群组成和功能宏基因组,使Akk菌属和与肥胖负相关的Christensenellaceae增加,并改变血液胆汁酸池。
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Probiotic or synbiotic alters the gut microbiota and metabolism in a randomised controlled trial of weight management in overweight adults

在超重成人体重管理的一项随机对照试验中,益生菌或合生制剂改变肠道菌群和代谢

10.3920/BM2018.0028

2018-12-10, Article

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The gut microbiota contributes to host energy metabolism, and altered gut microbiota has been associated with obesity-related metabolic disorders. We previously reported that a probiotic alone or together with a prebiotic controls body fat mass in healthy overweight or obese individuals in a randomised, double-blind, placebo controlled clinical study (ClinicalTrials.gov NCT01978691). We now aimed to investigate whether changes in the gut microbiota may be associated with the observed clinical benefits. Faecal and plasma samples were obtained from a protocol compliant subset (n=134) of participants from a larger clinical study where participants were randomised (1:1:1:1) into four groups: (1) placebo, 12 g/d microcrystalline cellulose; (2) Litesse® Ultra™ polydextrose (LU), 12 g/day; (3) Bifidobacterium animalis subsp. lactis 420™ (B420), 10 cfu/d in 12 g microcrystalline cellulose; (4) LU+B420, 1010 cfu/d of B420 in 12 g/d LU for 6 months of intervention. The faecal microbiota composition and metabolites were assessed as exploratory outcomes at baseline, 2, 4, 6 months, and +1 month post-intervention and correlated to obesity-related clinical outcomes. Lactobacillus and Akkermansia were more abundant with B420 at the end of the intervention. LU+B420 increased Akkermansia, Christensenellaceae and Methanobrevibacter, while Paraprevotella was reduced. Christensenellaceae was consistently increased in the LU and LU+B420 groups across the intervention time points, and correlated negatively to waist-hip ratio and energy intake at baseline, and waist-area body fat mass after 6 months treatment with LU+B420. Functional metagenome predictions indicated alterations in pathways related to cellular processes and metabolism. Plasma bile acids glycocholic acid, glycoursodeoxycholic acid, and taurohyodeoxycholic acid and tauroursodeoxycholic acid were reduced in LU+B420 compared to Placebo. Consumption of B420 and its combination with LU resulted in alterations of the gut microbiota and its metabolism, and may support improved gut barrier function and obesity-related markers.

First Authors:
A A Hibberd

Correspondence Authors:
A A Hibberd

All Authors:
A A Hibberd,C C Yde,M L Ziegler,A H Honoré,M T Saarinen,S Lahtinen,B Stahl,H M Jensen,L K Stenman

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