膳食磷脂与大脑认知功能(综述)
创作:orchid 审核:mildbreeze 04月26日
  • 磷脂是三大膜脂之一,包含不同种类,是大脑的重要组分,与大脑健康和功能相关;
  • 临床前和/或临床研究显示,在不同的生命阶段(生命早期、成年、老年)以及健康和疾病状态中(如慢性压力和衰老相关神经疾病),富含磷脂的饮食(如牛奶、蛋黄和大豆等)和/或补充磷脂对认知功能有积极影响;
  • 磷脂可能通过影响神经传递和神经可塑性、细胞内信号(如PI3K/Akt)、下丘脑-垂体-肾上腺轴以及菌群-肠-脑轴等机制,来发挥健脑作用。
主编推荐语
mildbreeze
《Neuroscience and Biobehavioral Reviews》近期发表的一篇综述,探讨了膳食磷脂的来源、在不同生命阶段和健康状态下对大脑认知功能的影响、潜在的作用机制,以及未来研究方向,推荐专业人士参考。
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Dietary Phospholipids: Role in Cognitive Processes Across the Lifespan

膳食磷脂:在整个生命周期的认知过程中的作用

10.1016/j.neubiorev.2020.01.012

01-13, Review

Abstract & Authors:展开

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Chronic stress and ageing are two of the most important factors that negatively affect cognitive processes such as learning and memory across the lifespan. To date, pharmacological agents have been insufficient in reducing the impact of both on brain health, and thus, novel therapeutic strategies are required. Recent research has focused on nutritional interventions to modify behaviour and reduce the deleterious consequences of both stress and ageing. In this context, emerging evidence indicate that phospholipids, a specific type of fat, are capable of improving a variety of cognitive processes in both animals and humans. The mechanisms underlying these positive effects are actively being investigated but as of yet are not fully elucidated. In this review, we summarise the preclinical and clinical studies available on phospholipid-based strategies for improved brain health across the lifespan. Moreover, we summarize the hypothesized direct and indirect mechanisms of action of these lipid-based interventions which may be used to promote resilience to stress and improve age-related cognitive decline in vulnerable populations.

First Authors:
Marina Schverer

Correspondence Authors:
Harriët Schellekens,John F Cryan

All Authors:
Marina Schverer,Siobhain M O'Mahony,Kenneth J O'Riordan,Francisco Donoso,Bernard L Roy,Catherine Stanton,Timothy G Dinan,Harriët Schellekens,John F Cryan

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