2岁前的肠道菌群发育,可能影响儿童时期的BMI
创作:szx 审核:szx 2018年10月27日
  • 在一项纳入165名挪威新生儿的前瞻性队列研究中,分析婴儿出生后第4、10、30、120、365、730天时的肠道菌群,并分析菌群与12岁时的BMI的关联;
  • 在出生后第10天及第730天(2岁时)的肠道菌群与12岁时的BMI显著相关,2岁时的肠道菌群分类群可解释超过50%的BMI差异;
  • 可预测12岁时的BMI的肠道菌群分类群集合,和那些与母亲超重/肥胖及孕期过度增重相关的母亲肠道菌群分类群有所重叠。
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szx
mBio上发表的一项前瞻性队列研究结果,发现新生儿在2岁之前的肠道菌群发育,与12岁时的BMI有显著关联,提示生命早期的肠道菌群可用于预测儿童肥胖的风险。
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mBio [IF:6.784]

Gut Microbiota in the First 2 Years of Life and the Association with Body Mass Index at Age 12 in a Norwegian Birth Cohort

挪威出生队列中出生后前两年的肠道菌群与12岁时的BMI的关联

10.1128/mBio.01751-18

2018-10-23, Article

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Childhood obesity is a growing problem worldwide. Recent research suggests that the gut microbiota may play an important and potentially causal role in the development of obesity and may be one mechanism that explains the transgenerational transmission of obesity risk. Here we examine the early-life gut microbiota at days 4, 10, 30, 120, 365, and 730 and the association with body mass index (BMI) z-scores at age 12 in a Norwegian prospective cohort (n = 165), and evaluate how these BMI-associated taxa relate to maternal overweight/obesity (Ow/Ob) and excessive gestational weight gain (GWG). We performed 16S rRNA gene sequencing on the gut microbiota samples. Taxonomic phylogeny at days 10 and 730 was significantly associated with childhood BMI, and the gut microbiota taxa at two years of age explained over 50% of the variation in childhood BMI in this cohort. The subset of the early-life taxa within the gut microbiota that best predicted later childhood BMI showed substantial overlap with the maternal taxa most strongly associated with maternal Ow/Ob and excessive GWG. Our results show an association between the infant gut microbiota and later BMI, and they offer preliminary evidence that the infant gut microbiota, particularly at 2 years of age, may have potential to help identify children at risk for obesity.

First Authors:
Maggie A Stanislawski,Merete Eggesbø

Correspondence Authors:
Maggie A Stanislawski

All Authors:
Maggie A Stanislawski,Dana Dabelea,Brandie D Wagner,Nina Iszatt,Cecilie Dahl,Marci K Sontag,Rob Knight,Catherine A Lozupone,Merete Eggesbø

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