翟齐啸+崔玉军:特定基因型的益生菌或能促进宿主长寿
  • 分析418株人源长双歧杆菌(BL)基因组,鉴定出BL的3个地理种群;
  • 不同BL种群间的差异主要体现在胞壁生物合成和碳水化合物代谢基因上;
  • BL在个体间、家庭间和地域间活跃传播,同一个体的不同菌株似乎源自单一的BL克隆;
  • BL的相对丰度随宿主衰老而降低,但特定的BL基因型特征(如精氨酸生物合成通路的SNP)与年龄正相关;
  • 小鼠中,不同精氨酸合成基因变异的BL菌株可能通过调节肠道菌群代谢,对D-半乳糖诱导的衰老施加不同的保护效应。
主编推荐语
mildbreeze
肠道细菌不同菌株在遗传和分子方面的差异,可能对宿主健康造成不同的影响。江南大学翟齐啸、军事医学科学院微生物流行病研究所崔玉军与研究团队在Microbiome发表最新研究成果,通过对4个大陆、17个国家的400多个长双歧杆菌菌株进行群体基因组学分析,结合小鼠模型的体内实验,探究了这种普遍存在于人类肠道中的益生菌的演化、传播和与宿主表型(如衰老)的关联,表明有特定遗传特征的益生菌株或能用于促进宿主长寿。该研究也为肠道细菌与宿主的共演化及其传播提供了新见解,也提示益生菌和活体生物药的“本地化”施用或有助于增强其有益作用。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
Microbiome [IF:14.65]

Human gut-derived B. longum subsp. longum strains protect against aging in a D-galactose-induced aging mouse model

人肠源长双歧杆菌长亚种菌株在D-半乳糖诱导的衰老小鼠模型中保护抵抗衰老

10.1186/s40168-021-01108-8

2021-09-01, Article

Abstract & Authors:展开

Abstract:收起
Background: Probiotics have been used to regulate the gut microbiota and physiology in various contexts, but their precise mechanisms of action remain unclear.
Results: By population genomic analysis of 418 Bifidobacterium longum strains, including 143 newly sequenced in this study, three geographically distinct gene pools/populations, BLAsia1, BLAsia2, and BLothers, were identified. Genes involved in cell wall biosynthesis, particularly peptidoglycan biosynthesis, varied considerably among the core genomes of the different populations, but accessory genes that contributed to the carbohydrate metabolism were significantly distinct. Although active transmission was observed inter-host, inter-country, inter-city, intra-community, and intra-family, a single B. longum clone seemed to reside within each individual. A significant negative association was observed between host age and relative abundance of B. longum, while there was a strong positive association between host age and strain genotype [e.g., single nucleotide polymorphisms in the arginine biosynthesis pathway]. Further animal experiments performed with the B. longum isolates via using a D-galactose-induced aging mouse model supported these associations, in which B. longum strains with different genotypes in arginine biosynthesis pathway showed divergent abilities on protecting against host aging possibly via their different abilities to modify the metabolism of gut microbes.
Conclusions: This is the first known example of research on the evolutionary history and transmission of this probiotic species. Our results propose a new mechanistic insight for promoting host longevity via the informed use of specific probiotics or molecules.

First Authors:
Yue Xiao

Correspondence Authors:
Yujun Cui,Qixiao Zhai

All Authors:
Yue Xiao,Chao Yang,Leilei Yu,Fengwei Tian,Yarong Wu,Jianxin Zhao,Hao Zhang,Ruifu Yang,Wei Chen,Colin Hill,Yujun Cui,Qixiao Zhai

评论