灵长类动物模型助力研究婴儿“拘束气质”
创作:尹小甜 审核:Epi汪 2021年06月18日
  • 在恒河猴中,婴儿期得分判断拘束气质(inhibited temperament,IT)的个体,在成年后更有可能拒绝人类的治疗措施;
  • 通过一个多世代大家族的猴子样本,发现婴儿的IT是部分可遗传的,其反映了一个共同的遗传底物;
  • 对106只猴子进行全基因组测序,发现存在与IT相关的单核苷酸变异(SNV);
  • 其中在CTNNA2附近有一个显著的SNV,或许是值得研究的分子靶点;
  • 此外,初步在神经质和抑郁症人类中也发现类似的基因关联。
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Epi汪
针对儿童性格特点开展的“气质类型”研究是心理学研究的热点话题。本研究借助灵长类动物模型,发现具备“拘束气质”的婴幼儿,未来的行为方式不一样,并且这种“气质”具有一定的遗传学基础。本研究为进一步揭示人类焦虑和抑郁的长期遗传风险提供了理论基础。
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Infant inhibited temperament in primates predicts adult behavior, is heritable, and is associated with anxiety-relevant genetic variation

灵长类动物的婴儿拘束气质预示着成年人的行为,其是可遗传的且与焦虑相关的遗传变异有关

10.1038/s41380-021-01156-4

2021-05-25, Article

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An anxious or inhibited temperament (IT) early in life is a major risk factor for the later development of stress-related psychopathology. Starting in infancy, nonhuman primates, like humans, begin to reveal their temperament when exposed to novel situations. Here, in Study 1 we demonstrate this infant IT predicts adult behavior. Specifically, in over 600 monkeys, we found that individuals scored as inhibited during infancy were more likely to refuse treats offered by potentially-threatening human experimenters as adults. In Study 2, using a sample of over 4000 monkeys from a large multi-generational family pedigree, we demonstrate that infant IT is partially heritable. The data revealed infant IT to reflect a co-inherited substrate that manifests across multiple latent variables. Finally, in Study 3 we performed whole-genome sequencing in 106 monkeys to identify IT-associated single-nucleotide variations (SNVs). Results demonstrated a genome-wide significant SNV near CTNNA2, suggesting a molecular target worthy of additional investigation. Moreover, we observed lower p values in genes implicated in human association studies of neuroticism and depression. Together, these data demonstrate the utility of our model of infant inhibited temperament in the rhesus monkey to facilitate discovery of genes that are relevant to the long-term inherited risk to develop anxiety and depressive disorders.

First Authors:
Andrew S Fox,Ronald A Harris

Correspondence Authors:
Andrew S Fox,Jeffrey Rogers

All Authors:
Andrew S Fox,Ronald A Harris,Laura Del Rosso,Muthuswamy Raveendran,Shawn Kamboj,Erin L Kinnally,John P Capitanio,Jeffrey Rogers

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