黄酮类化合物对肥胖的调节作用(综述)
创作:楸楸 审核:EADGBE 2020年10月29日
  • 生活方式和饮食习惯是决定肥胖发生和发展的主要因素,而脂质代谢异常与肥胖密切相关;
  • 黄酮类化合物可抑制小鼠摄食与体重增加,或与瘦素的分泌减少有关;
  • 黄酮类化合物通过降低对脂肪和糖类的消化吸收、调节脂质代谢、增加能量消耗以及调节肠道菌群来改善肥胖;
  • 芹菜素、金雀异黄素、山奈酚、杨梅素和柚皮素等黄酮类化合物在体内外有抗肥胖作用,有广阔的应用前景;
  • 需进一步研究黄酮类化合物抗肥胖作用的有效剂量、副作用和具体机制。
主编推荐语
EADGBE
肥胖是一个全球性的健康问题。超重和肥胖的主要危害在于导致严重的健康后果,是2型糖尿病、心血管疾病、高血压、中风和某些癌症的危险因素。随着生活方式的改变,减肥药物疗法作为辅助治疗越来越受欢迎。然而,现有的药物疗法由于严重的不良反应或效果较差而受到限制。多年来,天然产物一直是药物研发中先导化合物的重要来源。其中,水果和蔬菜中的黄酮类化合物具有重要的生物学效应和促进健康的作用。发表在Medicinal Research Reviews上的一篇综述文章,就黄酮类化合物对肥胖的调节作用及其预防或治疗肥胖的可能作用机制进行了综述,并强调了未来药理应用的新前景。
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Flavonoids as antiobesity agents: A review

黄酮类化合物作为抗肥胖药的综述

10.1002/med.21740

2020-10-20, Review

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Abstract:收起
Obesity is a global health problem that affects all age groups in both developing and developed countries. In recent years, the prevalence of overweight and obesity has reached pandemic levels, resulting in a dramatic increase in the incidence of various comorbidities, such as cardiovascular diseases, type 2 diabetes, and cancer, consequently leading to massive health and socioeconomic burdens. Together with lifestyle changes, antiobesity pharmacotherapy is gaining momentum as an adjunctive treatment. However, the available pharmacological approaches have limited use owing to either significant adverse effects or low efficacy. Over the years, natural products have been an important source of lead compounds for drug discovery. Among these, flavonoids are associated with important biological effects and health‐promoting activities. In this review, we discuss the modulatory effects of flavonoids on obesity and their potential mechanisms of action. The literature strongly suggests that most common flavonoids demonstrate a pronounced effect on obesity as shown by their ability to lower body weight, fat mass, and plasma triglycerides/cholesterol, both in in vitro and in vivo models. The impact of flavonoids on obesity can be observed through different mechanisms: reducing food intake and fat absorption, increasing energy expenditure, modulating lipid metabolism, or regulating gut microbiota profile. A better understanding of the known antiobesity mechanisms of flavonoids will enable their potential use to treat this medical condition. Therefore, this review focuses on the putative biological mechanisms through which flavonoids may prevent or treat obesity and highlights new perspectives on future pharmacological use.

First Authors:
Ana T Rufino

Correspondence Authors:
Ana T Rufino,Eduarda Fernandes

All Authors:
Ana T Rufino,Vera M Costa,Félix Carvalho,Eduarda Fernandes

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