含糖饮料摄入或增加2型糖尿病风险
创作:szx 审核:szx 2019年08月10日
  • 纳入4719名18-30岁的受试者(包括白人及黑人)进行一项前瞻性队列研究,分析人工甜味剂饮料(ASB)及含糖饮料(SSB)摄入与2型糖尿病(T2D)风险之间的关联;
  • 在30年的随访期间,680名受试者发展出T2D;
  • 校正生活方式、饮食质量、饮食习惯后,每摄入1份ASB与T2D风险增加12%显著相关,在校正基础BMI及体重变化后关联性消失;
  • 校正生活方式、饮食习惯、基础BMI及体重变化后,每摄入1份SSB或SSB+ASB,分别与T2D风险增加6%或5%显著相关。
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American Journal of Clinical Nutrition上发表的一项前瞻性队列研究结果,对近5000名受试者进行30年随访后发现,含糖饮料的摄入与2型糖尿病风险增加显著相关,而人工甜味剂饮料与2型糖尿病风险的关联受到体重变化及BMI的影响。
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Cumulative intake of artificially sweetened and sugar-sweetened beverages and risk of incident type 2 diabetes in young adults: the Coronary Artery Risk Development In Young Adults (CARDIA) Study

人工甜味剂饮料及含糖饮料的累积摄入与年轻人的2型糖尿病风险

10.1093/ajcn/nqz154

2019-08-02, Article

Abstract & Authors:展开

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Background: Epidemiological evidence has demonstrated a positive association between artificially sweetened beverage (ASB) and sugar-sweetened beverage (SSB) consumption and type 2 diabetes (T2D) risk. However, research informing this topic in young adults is limited.
Objective: This study examined the association between ASB, SSB, and total sweetened beverage (TSB; combined ASB and SSB) consumption and T2D risk in young adults.
Methods: A prospective analysis of 4719 Black and White men and women aged 18–30 y at baseline was conducted from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Each participant's beverage intake was assessed using the CARDIA Diet History at baseline and at study Years 7 and 20. Multivariable Cox proportional hazards regression models were used to examine cumulative average ASB, SSB, and TSB intakes and risk of T2D.
Results: During the 30-y follow-up period, 680 participants developed T2D. ASB consumption was associated with a 12% greater risk of T2D per serving/day (HR 1.12, 95% CI 1.04–1.20) in a model adjusted for lifestyle factors, diet quality, and dieting behavior. Further adjustments for baseline BMI (HR 1.07, 95% CI 0.99–1.14) and weight change during follow-up (HR 1.04, 95% CI 0.97–1.12) attenuated the association. SSB and TSB consumption as continuous variables per 1 serving/day of intake were associated with 6% and 5% increased risks of T2D, respectively (HRSSB 1.06, 95% CI 1.01–1.10; HRTSB 1.05, 95% CI 1.01–1.09), in the model accounting for lifestyle factors, dieting behavior, baseline BMI, and weight change. Results were consistent when the exposures were modeled in categories of consumption and quintiles.
Conclusions: In young adults, long-term ASB, SSB, and TSB consumption were associated with increased risks of T2D. However, the estimates for ASB were attenuated when accounting for weight changes.

First Authors:
Kristin M Hirahatake

Correspondence Authors:
Andrew O Odegaard

All Authors:
Kristin M Hirahatake,David R Jacobs Jr,James M Shikany,Luohua Jiang,Nathan D Wong,Lyn M Steffen,Andrew O Odegaard

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