特定益生菌酸奶或可改善超重/肥胖孕妇的糖代谢
创作:梁婷 审核:mildbreeze 2019年06月02日
  • 130名孕22周时BMI≥25、空腹血糖正常的孕妇随机分为2组,从孕24周起每天补充益生菌酸奶(嗜酸乳杆菌La5+乳双歧杆菌Bb12)或传统酸奶;
  • 干预4周后,益生菌组的基线和空腹血糖、2h口服糖耐量测试(OGTT)均显著较低,但两组的1h OGTT差异不显著;
  • 益生菌组婴儿的胆红素水平在出生后第3-5天显著较低;
  • 两组间妊娠期糖尿病风险、早产以及其它母婴结局无显著差异;
  • 特定益生菌对超重/肥胖孕妇的糖代谢有一定益处,其临床意义需进一步研究。
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《European Journal of Nutrition》发表的一项临床试验表明,补充含嗜酸乳杆菌La5和乳双歧杆菌Bb12的益生菌酸奶,对超重/肥胖孕妇的糖代谢或有一定改善效果。
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Effect of probiotic yoghurt on plasma glucose in overweight and obese pregnant women: a randomized controlled clinical trial

益生菌酸奶对超重和肥胖孕妇血糖的影响:一项随机对照临床试验

10.1007/s00394-019-01900-1

2019-05-08, Article

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Abstract:收起
INTRODUCTION:: There is only some evidence about effectiveness of probiotics for preventing gestational hyperglycaemia. This trial examined the effects of probiotic yoghurts containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 on maternal plasma glucose (primary outcome) and on some maternal and infant complications (secondary outcomes) in overweight and obese women with no diabetes in pregnancy.
METHODS: Using stratified block randomization, women with pre- or early-pregnancy BMI ≥ 25 and fasting plasma glucose < 92 mg/dl at 22 weeks of gestation were assigned into probiotic or conventional yoghurt group, consuming 100 g/day from 24 weeks of gestation until delivery. The women and their infants were followed up until 1 month after birth.
RESULTS: In each group, one out of 65 women had intra-uterine foetal death and were not analysed for other outcomes. The mean BMI was 29.2 (SD 3.3) in probiotic and 30.3 (SD 4.1) in conventional yoghurt group. Four weeks after initiation of the treatment, plasma glucose levels were significantly lower in the probiotic than in conventional yoghurt group at fasting (mean difference adjusted for the BMI category) and baseline FPG (- 4.0 mg/dl; 95% confidence interval - 6.9, - 1.1) and 2-h OGTT (- 13.9; - 22.8, - 5.0). At the 1-h OGTT, however, the difference was not statistically significant (- 9.8; - 20.6, 0.9). Further, there was a significantly lower infant bilirubin level in the probiotic group on days 3-5 after birth (- 2.2 mg/dl; - 3.3, - 1.2). There were not statistically significant differences between the groups regarding the risk of gestational diabetes (6 vs 11; odds ratio 0.5; 0.2, 1.5), preterm delivery (3 vs 8; 0.3; 0.1, 1.2), and other maternal and infant outcomes.
CONCLUSION: The probiotics supplementation has some beneficial effects on glucose metabolism of overweight and obese pregnant women. Nevertheless, further studies are required to judge the clinical significance of such effects.

First Authors:
Hanieh Asgharian

Correspondence Authors:
Sakineh Mohammad‑Alizadeh‑Charandabi

All Authors:
Hanieh Asgharian,Aziz Homayouni‑Rad,Mojgan Mirghafourvand,Sakineh Mohammad‑Alizadeh‑Charandabi

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