国内团队:揭示原发性甲状腺功能减退相关的肠道菌群紊乱
  • 分析52例原发性甲状腺功能减退患者和40位健康对照的肠道菌群,发现两者肠道菌群的α和β多样性具有显著差异;
  • 韦荣氏球菌属、Paraprevotella、奈瑟菌属、伦黑墨氏菌属等4种肠道细菌可用于区分未经治疗的原发性甲状腺功能减退患者和健康人,且精确度最高;
  • 原发性甲状腺功能减退患者的肠道产生短链脂肪酸的能力明显降低,导致血清脂多糖水平升高;
  • 将原发性甲状腺功能减退患者的粪便菌群移植到小鼠,导致小鼠的总甲状腺素水平下降。
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爱的抉择
肠道菌群与甲状腺疾病相关,包括甲亢、慢性甲状腺炎、甲状腺结节和甲状腺癌。Clinical Science最近发表来自山东省立医院团队的文章,揭示了原发性甲状腺功能减退患者的肠道菌群明显发生变化,而粪菌移植表明肠道菌群的改变会影响小鼠的甲状腺功能。这有助于我们对于原发性甲状腺功能减退疾病的理解,或为发展抗生素的联用治疗策略提供参考。
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Clinical Science [IF:5.223]

Gut dysbiosis is associated with primary hypothyroidism with interaction on gut-thyroid axis

肠-甲状腺轴互作与原发性甲状腺功能减退相关的肠道菌群紊乱有关

10.1042/CS20200475

06-10, Article

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Background: Previous studies have shown that the gut microbiome is associated with thyroid diseases, including Graves’ disease, Hashimoto’s disease, thyroid nodules, and thyroid cancer. However, the association between intestinal flora and primary hypothyroidism remains elusive. We aimed to characterize gut microbiome in primary hypothyroidism patients.
Methods: Fifty-two primary hypothyroidism patients and 40 healthy controls were recruited. The differences in gut microbiota between the two groups were analyzed by 16S rRNA sequencing technology. Fecal microbiota transplantation (FMT) was performed in mice using flora from both groups; changes in thyroid function were then assessed in the mice.
Results: There were significant differences in α and β diversities of gut microbiota between primary hypothyroidism patients and healthy individuals. The random forest analysis indicated that four intestinal bacteria (Veillonella, Paraprevotella, Neisseria, and Rheinheimera) could distinguish untreated primary hypothyroidism patients from healthy individuals with the highest accuracy; this was confirmed by receiver operator characteristic curve analysis. The short chain fatty acid producing ability of the primary hypothyroidism patients’ gut was significantly decreased, which resulted in the increased serum lipopolysaccharides (LPS) levels. The FMT showed that mice receiving the transplant from primary hypothyroidism patients displayed decreased total thyroxine levels.
Conclusions: Our study suggests that primary hypothyroidism causes changes in gut microbiome. In turn, an altered flora can affect thyroid function in mice. These findings could help understand the development of primary hypothyroidism and might be further used to develop potential probiotics to facilitate the adjuvant treatment of this disease.

First Authors:
Xinhuan Su

Correspondence Authors:
Shizhan Ma,Zhe Wang

All Authors:
Xinhuan Su,Ying Zhao,Yang Li,Shizhan Ma,Zhe Wang

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