Nature子刊:破坏生物膜、预防蛀牙的纳米材料
创作:女巫 审核:mildbreeze 2018年08月06日
  • Ferumoxytol是治疗铁缺乏的纳米颗粒制剂,具有依赖于pH的过氧化物酶样活性,可破坏顽固性口腔生物膜,防止蛀牙;
  • Ferumoxytol结合生物膜超的微结构,并从过氧化氢(H2O2)中产生自由基,通过破坏细菌细胞膜和降解细胞外聚合物基质,导致原位细菌死亡;
  • 联合低浓度的H2O2,Ferumoxytol抑制牙齿上的生物膜积聚,防止矿化组织的酸损伤;
  • 局部施用Ferumoxytol,对牙龈、粘膜和口腔菌群多样性无不良影响,可用于治疗生物膜引起的口腔疾病。
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mildbreeze
Ferumoxytol是一种氧化铁纳米颗粒,被FDA批准用于治疗铁缺乏。Nature Communications近期发表的一项研究,发现这种纳米材料还能用于破坏口腔生物膜、预防蛀牙,有转化应用前景。
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Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity

局部ferumoxytol纳米颗粒在体内通过固有的催化活性破坏生物膜,防止蛀牙

10.1038/s41467-018-05342-x

2018-07-31, Article

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Ferumoxytol is a nanoparticle formulation approved by the U.S. Food and Drug Administration for systemic use to treat iron deficiency. Here, we show that, in addition, ferumoxytol disrupts intractable oral biofilms and prevents tooth decay (dental caries) via intrinsic peroxidase-like activity. Ferumoxytol binds within the biofilm ultrastructure and generates free radicals from hydrogen peroxide (HO), causing in situ bacterial death via cell membrane disruption and extracellular polymeric substances matrix degradation. In combination with low concentrations of HO, ferumoxytol inhibits biofilm accumulation on natural teeth in a human-derived ex vivo biofilm model, and prevents acid damage of the mineralized tissue. Topical oral treatment with ferumoxytol and HO suppresses the development of dental caries in vivo, preventing the onset of severe tooth decay (cavities) in a rodent model of the disease. Microbiome and histological analyses show no adverse effects on oral microbiota diversity, and gingival and mucosal tissues. Our results reveal a new biomedical application for ferumoxytol as topical treatment of a prevalent and costly biofilm-induced oral disease.

First Authors:
Yuan Liu

Correspondence Authors:
Hyun Koo

All Authors:
Yuan Liu,Pratap C Naha,Geelsu Hwang,Dongyeop Kim,Yue Huang,Aurea Simon-Soro,Hoi-In Jung,Zhi Ren,Yong Li,Sarah Gubara,Faizan Alawi,Domenick Zero,Anderson T Hara,David P Cormode,Hyun Koo

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