吴清平院士:益生菌或有益于缓解三高症状(综述)
创作:梁婷 审核:兵兵 2020年09月10日
  • 共纳入13项研究,包括8个国家的818名受试者,评估益生菌摄入方式对2型糖尿病患者的血糖、血脂、血压和炎症因子的影响;
  • 补充单菌,空腹血糖(FBS)、胰岛素抵抗(HOMA-IR)和舒张压(DBP)显著降低;
  • 补充混菌,HOMA-IR, 甘油三酯(TG),高密度脂蛋白胆固醇(HDL-C),收缩压(SBP)和TNF-α显著改善;
  • 益生菌加入到食品中时,HOMA-IR和TG显著降低;
  • FBS、HMOA-IR、TG、SBP和DBP显著受患者年龄、BMI、国家和摄入持续时间的影响。
主编推荐语
兵兵
广东省微生物研究所吴清平院士研究团队发表在Critical Reviews in Food Science and Nutrition上的文章。文章系统综述了现有研究中关于益生菌与高血糖、高血压和高血脂的相关性。现有的研究表明,长期补充(最好8周以上)益生菌(尤其是混菌)对缓解55岁以下,BMI小于30的人群三高症状具有一定的作用。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Probiotics supplementation improves hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes mellitus: An update of meta-analysis

补充益生菌可改善2型糖尿病患者的高血糖、高胆固醇血症和高血压:一项最新的荟萃分析

10.1080/10408398.2020.1764488

2020-05-21, Review

Abstract & Authors:展开

Abstract:收起
Although many studies have shown that consumption of probiotics is relevant to diabetes, the effects of probiotics improves clinical outcomes in type 2 diabetes have yielded conflicting results. The aim of this meta-analysis was conducted to assess the effects of probiotics supplementation on glycemic, blood lipids, pressure and inflammatory control in type 2 diabetes. PubMed, Web of science, Embase and the Cochrane Library databases were searched for relevant studies from February 2015 up to Janurary 2020, with no language restrictions. The pooled results were calculated with the use of a random-effects model to assess the impact of supplemental probiotics on glycemic, blood lipids, pressure and inflammatory control in type 2 diabetes. Additionally, subgroup analysis was conducted based on patients age, body mass index (BMI), country and duration of the probiotics supplement, respectively. 13 studies were included in this meta-analysis, involving a total of 818 participants in 8 countries. Overall, compared with control groups, the subjects who received multiple species of probiotics had a statistically significant reduction in fasting blood sugar (FBS), homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol (TC), triglycerides (TG), systolic blood pressure (SBP), diastolic blood pressure (DBP) and tumor necrosis factor (TNF) -α [standardized mean difference (SMD): -0.89 mg/Dl, 95% CI: -1.66, -0.12 mg/dL; SMD: -0.43, 95% CI: -0.63, -0.23; SMD: -0.19 mg/dL, 95% CI: -0.36, -0.01 mg/dL; SMD: -0.23 mg/dL, 95% CI: -0.40, -0.05 mg/dL; SMD: -5.61 mmHg, 95% CI: -9.78, -1.45 mmHg; SMD: -3.41 mmHg, 95% CI: -6.12, -0.69 mmHg; and SMD: 6.92 pg/ml, 95% CI: 5.95, 7.89 pg/ml, respectively]. However, the subjects who received single-species of probiotic or probiotic with co-supplements in food only changed FBS, HOMA-IR, DBP and TG levels. Moreover, subgroup analyses revealed that the effects of probiotics supplementation on FBS, HMOA-IR, SBP and DBP are significantly influenced by patients age, body mass index (BMI), country and duration of the probiotics supplement. Our analysis revealed that glycemic, lipids, blood pressure and inflammation indicators are significantly improved by probiotic supplementation, particularly the subjects who ages ≤ 55, baseline BMI< 30 kg/m, duration of intervention more than 8 weeks, and received multiple species probiotic.

First Authors:
Tingting Liang

Correspondence Authors:
Qingping Wu

All Authors:
Tingting Liang,Lei Wu,Yu Xi,Ying Li,Xinqiang Xie,Congcong Fan,Lingshuang Yang,Shuanghong Yang,Xuefeng Chen,Jumei Zhang,Qingping Wu

评论