塑造肠道菌群:驯化与工业化并进
创作:白蓝木 审核:solo 03月31日
  • 比较野生和家养动物及黑猩猩和人类的肠道菌群,发现驯化显著影响肠道微生态,影响效应和人类工业化类似;
  • 小鼠和犬科动物中,驯化与野生肠道菌群组成的不同可由饮食互换而逆转;
  • 驯化造成的细菌消失无法通过饮食复得,但可通过实验手段在小鼠中定植“野生样”微生物;
  • 尽管本质上不同,研究提示驯化和工业化可能通过共同的生态变化以相关的方式影响肠道菌群;
  • 驯化动物模型在人类研究及宿主和菌群共进化的领域中兼具实用性和局限性。
主编推荐语
solo
elife上近期发表的文章,阐述人类对动物的驯化家养对不同物种的肠道菌群起着显著地、类似地影响。在进化过程中塑造动物肠道微生物组上,驯化或可与饮食、宿主生理等因素相提并论。且类似的影响也体现在人类和猩猩肠道菌群的不同中。不禁让人感叹,是否在某个时间点我们也将自己驯化了呢?
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eLife [IF:7.08]

Effects of domestication on the gut microbiota parallel those of human industrialization

驯化对肠道菌群的影响平行于人类工业化

10.7554/eLife.60197

03-23, Article

Abstract & Authors:展开

Abstract:收起
Domesticated animals experienced profound changes in diet, environment, and social interactions that likely shaped their gut microbiota and were potentially analogous to ecological changes experienced by humans during industrialization. Comparing the gut microbiota of wild and domesticated mammals plus chimpanzees and humans, we found a strong signal of domestication in overall gut microbial community composition and similar changes in composition with domestication and industrialization. Reciprocal diet switches within mouse and canid dyads demonstrated the critical role of diet in shaping the domesticated gut microbiota. Notably, we succeeded in recovering wild-like microbiota in domesticated mice through experimental colonization. Although fundamentally different processes, we conclude that domestication and industrialization have impacted the gut microbiota in related ways, likely through shared ecological change. Our findings highlight the utility, and limitations, of domesticated animal models for human research and the importance of studying wild animals and non-industrialized humans for interrogating signals of host–microbial coevolution.

First Authors:
Aspen T Reese

Correspondence Authors:
Aspen T Reese,Rachel N Carmody

All Authors:
Aspen T Reese,Katia S Chadaideh,Caroline E Diggins,Laura D Schell,Mark Beckel,Peggy Callahan,Roberta Ryan,Melissa Emery Thompson,Rachel N Carmody

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