多摄入亚油酸或有益于心血管健康
创作:楸楸 审核:szx 2020年12月27日
  • 纳入22名有症状和23名无症状的颈动脉疾病患者;
  • 气相色谱法测定红细胞和颈动脉斑块磷脂中的全反式油酸、亚油酸(LA, C18:2n6)、α-亚麻酸 (C18:3n3)和ω‐3指数(二十碳五烯酸[C20:5n3]和二十二碳六烯酸[C22:6n3]酸的总和);
  • 校正地理、临床及饮食等多个变量后,红细胞和颈动脉斑块磷脂中的LA状态与有症状的颈动脉疾病的患病率呈负相关,提示膳食LA有益于血管健康。
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szx
红细胞的脂肪酸组成可客观反映长期的饮食脂肪酸摄入状态。来自Stroke上发表的一项最新研究,对比了有症状及无症状的颈动脉疾病患者的红细胞及颈动脉斑块磷脂中的特定脂肪酸(包括全反式油酸、亚油酸、α-亚麻酸、ω-3)水平,发现亚油酸状态与有症状的颈动脉疾病的患病率呈显著负相关,提示摄入亚油酸或有益于心血管健康。
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Stroke [IF:7.19]

Linoleic Acid Status in Cell Membranes Inversely Relates to the Prevalence of Symptomatic Carotid Artery Disease

细胞膜中的亚油酸状态与症状性颈动脉疾病的患病率成反比

10.1161/STROKEAHA.120.030477

2020-12-04, Article

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Background and Purpose: The red blood cell fatty acid composition objectively reflects the long-term dietary intake of several fatty acids. In patients undergoing carotid endarterectomy, we explored whether red blood cell status of selected fatty acids related to symptomatic carotid artery disease.
Methods: We included patients with symptomatic (n=22) and asymptomatic (n=23) carotid artery disease. We determined all-C18:1 trans, linoleic acid (LA, C18:2n6), alpha-linolenic acid (C18:3n3), and the omega-3 index (sum of eicosapentaenoic [C20:5n3] and docosahexaenoic [C22:6n3] acids) in both red blood cells and carotid plaque phospholipids by gas-chromatography.
Results: In a multivariate logistic regression analysis, we only observed a significant association for LA, whose red blood cell status was inversely related to symptomatic carotid artery disease (odds ratio, 0.116 [95% CI, 0.022–0.607], P=0.011, for each 1-SD increase). A similar result was observed for LA in carotid plaque phospholipids.
Conclusions: Cell membrane enrichment in LA, which reflects its intake, was inversely related to symptomatic carotid disease. This increases evidence supporting a favorable role of dietary LA in vascular health.

First Authors:
Iolanda Lázaro,Montserrat Cofán

Correspondence Authors:
Aleix Sala-Vila

All Authors:
Iolanda Lázaro,Montserrat Cofán,Antonio J Amor,Emilio Ortega,Tania-Marisa Freitas-Simoes,Laura Llull,Sergio Amaro,Gaspar Mestres,Xavier Yugueros,William S Harris,Vicente Riambau,Aleix Sala-Vila

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