Nature:Gordon团队设计菌群导向性纤维零食
  • 在定植肥胖者菌群+高脂低果蔬饲喂的悉生小鼠中,补充不同的果蔬纤维制剂引起了肠道菌群的纤维特异性应答,包括代谢通路、CAZyme和特定菌种丰度(尤其是拟杆菌)的变化;
  • 采用高脂低果蔬饮食的肥胖/超重者,用含1种、2种或4种纤维的零食进行干预,其菌群对纤维零食的应答模式与悉生小鼠有很大相似,4种纤维的零食引起最多的CAZyme变化;
  • 受试者菌群中CAZyme对不同纤维零食的应答,与反映生理状态改变的血浆蛋白质组的变化相关。
主编推荐语
mildbreeze
了解饮食如何影响肠道菌群从而影响人体健康,将会催生菌群靶向性的饮食策略,为促进人类健康开辟新道路。Jeffrey Gordon团队在Nature发表的一项最新研究,通过结合悉生小鼠模型和人体干预试验,为实现这一目标提供了一套参考研究流程。该研究细致分析了不同种类的源于常见果蔬的纤维制剂和零食原型对肠道菌群的组成和代谢功能的细微影响,并将菌群对纤维干预的应答与反映生理状态的血液标志物变化关联起来,为未来深入研究菌群靶向性饮食干预打下坚实的基础。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
Nature [IF:69.504]

Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans

在悉生小鼠和人体中评估微生物组导向的纤维零食

10.1038/s41586-021-03671-4

2021-06-23, Article

Abstract & Authors:展开

Abstract:收起
Changing food preferences brought about by westernization that have deleterious health effects1,2—combined with myriad forces that are contributing to increased food insecurity—are catalysing efforts to identify more nutritious and affordable foods3. Consumption of dietary fibre can help to prevent cardiovascular disease, type 2 diabetes and obesity4,5,6. A substantial number of reports have explored the effects of dietary fibre on the gut microbial community7,8,9. However, the microbiome is complex, dynamic and exhibits considerable intra- and interpersonal variation in its composition and functions. The large number of potential interactions between the components of the microbiome makes it challenging to define the mechanisms by which food ingredients affect community properties. Here we address the question of how foods containing different fibre preparations can be designed to alter functions associated with specific components of the microbiome. Because a marked increase in snack consumption is associated with westernization, we formulated snack prototypes using plant fibres from different sustainable sources that targeted distinct features of the gut microbiomes of individuals with obesity when transplanted into gnotobiotic mice. We used these snacks to supplement controlled diets that were consumed by adult individuals with obesity or who were overweight. Fibre-specific changes in their microbiomes were linked to changes in their plasma proteomes indicative of an altered physiological state.

First Authors:
Omar Delannoy-Bruno

Correspondence Authors:
Jeffrey I Gordon

All Authors:
Omar Delannoy-Bruno,Chandani Desai,Arjun S Raman,Robert Y Chen,Matthew C Hibberd,Jiye Cheng,Nathan Han,Juan J Castillo,Garret Couture,Carlito B Lebrilla,Ruteja A Barve,Vincent Lombard,Bernard Henrissat,Semen A Leyn,Dmitry A Rodionov,Andrei L Osterman,David K Hayashi,Alexandra Meynier,Sophie Vinoy,Kyleigh Kirbach,Tara Wilmot,Andrew C Heath,Samuel Klein,Michael J Barratt,Jeffrey I Gordon

图片
Medical Xpress新闻网站

New snack foods nurture healthy gut microbiome

2021-06-24

图片
人体微生物组与健康微信公众号

Nature:新型含纤维零食可培育出健康的肠道微生物组

2021-07-15

评论