创作:unannotated 审核:szx 2017年05月02日
  • 对12个月大的大鼠分别喂食大豆油、猪油或鱼油3个月后,研究其肠道菌群结构;
  • 在体内和体外研究中,鱼油组中的大鼠肠道菌群结构与大豆油和猪油组的差异显着;
  • 鱼油组大鼠盲肠及结肠中的变形菌门和脱硫弧菌属的相对丰度最高,炎症标志物(包括IL-1β、IL-6、IL-17、IL-18级TNF-α)的mRNA水平也最高;
  • 同时,鱼油组中可能的脂质代谢相关微生物DNA丰度也最高;
  • 本研究从新的视角分析了鱼油饮食对中年群体健康的潜在负面影响。
Scientific Reports [IF:3.998]

Fish oil, lard and soybean oil differentially shape gut microbiota of middle-aged rats



2017-04-11, Article

Abstract & Authors:展开

High-fat diets have been associated with overweight/obesity and increased mortality in middle-aged populations. However, it is still unclear how gut microbiota in middle-aged populations responds to dietary fats at a normal dose. In this study, we explored gut microbiota structure in middle-aged rats (aged 12 months) after feeding 4% (w/w) soybean oil, lard or fish oil for 3 months, respectively. The results showed that the gut microbiota structure in the fish oil group was substantially different from those of the soybean oil and lard groups in both in vitro and in vivo studies. The relative abundances of phylum Proteobacteria and genus Desulfovibrio in the caecal and colonic contents were the highest in the fish oil group (p < 0.05). The mRNA levels of biomarkers for inflammation in the colon, including IL-1β, IL-6, IL-17, IL-18 and TNF-α, were also the highest in the fish oil group (p < 0.05). Meanwhile, the fish oil group had the highest microbial DNA abundance of a predicted lipid metabolism. Our results gave a new insight into the potentially negative impact of fish oil diet on health of middle-aged populations by changing gut microbiota and inducing inflammation as compared to soybean oil and lard diets.

First Authors:
He Li

Correspondence Authors:
Guanghong Zhou,Chunbao Li

All Authors:
He Li,Yingying Zhu,Fan Zhao,Shangxin Song,Yingqiu Li,Xinglian Xu,Guanghong Zhou,Chunbao Li