国内团队:补充槲皮素或可降低血压
创作:szx 审核:szx 2020年02月16日
  • 纳入17项RCT(共涉及896名受试者)进行荟萃分析,总结补充槲皮素对血浆脂质谱、血压水平及血糖水平的影响;
  • 补充槲皮素的剂量在30mg/天到1000mg/天不等,7项RCT为交叉试验,10项为平行试验;
  • 总体分析结果显示,槲皮素可显著降低收缩压与舒张压(分别降低3.09mmHg及2.86mmHg),对血浆脂质谱与血糖水平无显著影响;
  • 亚组分析结果显示,在平行试验中,补充槲皮素8周或以上的受试者,高密度脂蛋白胆固醇及甘油三酯显著降低。
主编推荐语
szx
在不同临床试验中,槲皮素的心血管保护作用存在争议。东莞市第三人民医院的黄浩海团队在Nutrition Reviews上发表的一项荟萃分析结果,对17项RCT研究进行总结后发现,补充槲皮素可显著降低血压,但对血糖及血浆脂质无显著影响。
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Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis

补充槲皮素对血浆脂质谱、血压及血糖的影响:系统性综述与荟萃分析

10.1093/nutrit/nuz071

2020-01-06, Article

Abstract & Authors:展开

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Context: Clinical trials examining the cardiovascular protective effects of quercetin in humans have reported conflicting results.
Objective: The aim of this systematic review was to summarize evidence of the effects of quercetin supplementation on plasma lipid profiles, blood pressure (BP), and glucose levels in humans by performing a meta-analysis of randomized controlled trials.
Data Sources: MEDLINE, Embase, and Scopus databases were searched electronically from their inception to July 2018 to identify randomized controlled trials that assessed the impact of quercetin on lipid profiles, BP, and glucose levels.
Study Selection: Randomized controlled trials assessing the effects of quercetin or a standardized quercetin-enriched extract on plasma lipid profiles, BP, and glucose levels in humans were eligible for inclusion.
Data Extraction: A random-effects model was used for data analysis. Continuous variables were expressed as weighted mean differences (WMDs) and 95%CIs. Subgroup analyses were conducted to explore possible influences of study characteristics. Sensitivity analyses were also performed, as were analyses of publication bias.
Results: Seventeen trials (n = 896 participants total) were included in the overall analysis. Pooled results showed that quercetin significantly lowered both systolic BP (WMD, −3.09 mmHg; 95%CI, −4.59 to −1.59; P = 0.0001) and diastolic BP (WMD, −2.86 mmHg; 95%CI, −5.09 to −0.63; P = 0.01). Neither lipid profiles nor glucose concentrations changed significantly. In subgroup analyses, significant changes in high-density lipoprotein cholesterol and triglycerides were observed in trials with a parallel design and in which participants consumed quercetin for 8 weeks or more.
Conclusion: Quercetin intake resulted in significantly decreased BP in humans. Moreover, participants who consumed quercetin for 8 weeks or more showed significantly changed levels of high-density lipoprotein cholesterol and triglycerides in trials with a parallel design.

First Authors:
Haohai Huang

Correspondence Authors:
Haohai Huang

All Authors:
Haohai Huang,Dan Liao,Yong Dong,Rong Pu

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