创作:小扣啊 审核:aluba 2017年10月02日
  • 比较从416对英国双胞胎获得的约1000个粪便样品中的菌群,鉴定出许多分类群的丰度受宿主遗传因素的影响;
  • 克氏菌科是可遗传性最高的分类群,与其他可遗传细菌和产甲烷古细菌形成了共生网络,这些细菌在体重指数较低的个体中更丰富;
  • 将克氏菌移植到小鼠中,小鼠体重增加减缓且肠道菌群组成发生变化;
  • 这些研究结果表明,人类遗传(人体自身基因)可能通过影响宿主代谢而塑造肠道菌群的组成。
蓝灿辉 | 热心肠先生
Cell [IF:38.637]

Human genetics shape the gut microbiome



2014-11-24, Article

Abstract & Authors:展开

BACKGROUND: Host genetics and the gut microbiome can both influence metabolic phenotypes. However, whether host genetic variation shapes the gut microbiome and interacts with it to affect host phenotype is unclear.
METHODS: Here, we compared microbiotas across >1,000 fecal samples obtained from the TwinsUK population, including 416 twin pairs.
RESULTS: We identified many microbial taxa whose abundances were influenced by host genetics. The most heritable taxon, the family Christensenellaceae, formed a co-occurrence network with other heritable Bacteria and with methanogenic Archaea. Furthermore, Christensenellaceae and its partners were enriched in individuals with low body mass index (BMI). An obese-associated microbiome was amended with Christensenella minuta, a cultured member of the Christensenellaceae, and transplanted to germ-free mice. C. minuta amendment reduced weight gain and altered the microbiome of recipient mice.
CONCLUSION: Our findings indicate that host genetics influence the composition of the human gut microbiome and can do so in ways that impact host metabolism.

First Authors:
Julia Goodrich

Correspondence Authors:
Ruth Ley

All Authors:
Julia Goodrich,Jillian L Waters,Angela C Poole,Jessica L Sutter,Omry Koren,Ran Blekhman,Michelle Beaumont,Willian Van Treuren,Rob Knight,Jordana T Bell,Timothy D Spector,Andrew G Clark,Ruth Ley