Science:免疫细胞怎样控制肠道的营养吸收?
创作:mildbreeze 审核:mildbreeze 04月01日
  • 小鼠的小肠上皮能响应膳食碳水化合物,根据其可用度“按需”诱导消化吸收碳水化合物所需酶和转运蛋白的转录程序,伴随肠上皮的重塑(改变不同肠细胞亚群的比例);
  • 这种“按需”的转录程序调控需要肠上皮与淋巴细胞间的互作回路,肠道γδ T细胞在其中起重要介导作用;
  • 机制上,高碳水饮食可改变γδ T细胞的肠隐窝定位和转录组,γδ T细胞通过抑制3型天然淋巴细胞生成IL-22,调控肠上皮的碳水化合物相关转录程序。
主编推荐语
mildbreeze
肠道是一个多功能的器官,不仅要吸收营养,还要时刻抵御微生物的入侵,因而肠道必须能应对营养和微生物等环境信号的变化而发生适应性改变。Science最新发表的研究,揭示了肠道中的一种免疫细胞——γδ T细胞在调控肠道对高碳水饮食适应方面的关键作用,以及其中的肠上皮-免疫互作机制。该研究不仅鉴定出γδ T细胞在免疫防御以外的新功能,将肠道的营养吸收与免疫因素联系起来,也为饮食相关代谢疾病中的免疫改变提供了新视角。
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Science [IF:41.845]

γδ T cells regulate the intestinal response to nutrient sensing

γδ T细胞调节肠道对营养感应的反应

10.1126/science.aba8310

03-19, Article

Abstract & Authors:展开

Abstract:收起
The intestine is a site of direct encounter with the external environment and must consequently balance barrier defense with nutrient uptake. To investigate how nutrient uptake is regulated in the small intestine, we tested the effect of diets with different macronutrient compositions on epithelial gene expression. We found that enzymes and transporters required for carbohydrate digestion and absorption were regulated by carbohydrate availability. The “on-demand” induction of this machinery required γδ T cells, which regulated this program through the suppression of interleukin-22 production by type 3 innate lymphoid cells. Nutrient availability altered the tissue localization and transcriptome of γδ T cells. Additionally, transcriptional responses to diet involved cellular remodeling of the epithelial compartment. Thus, this work identifies a role for γδ T cells in nutrient sensing.

First Authors:
Zuri A Sullivan

Correspondence Authors:
Ruslan Medzhitov

All Authors:
Zuri A Sullivan,William Khoury-Hanold,Jaechul Lim,Chris Smillie,Moshe Biton,Bernardo S Reis,Rachel K Zwick,Scott D Pope,Kavita Israni-Winger,Roham Parsa,Naomi H Philip,Saleh Rashed,Noah Palm,Andrew Wang,Daniel Mucida,Aviv Regev,Ruslan Medzhitov

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肠道菌群与代谢微信公众号

Science|γδT细胞调节肠道营养感知

2021-04-18

点评:非常好的全面解读

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