益生菌或可用于缓解焦虑
  • 纳入86名平均年龄20.59岁的健康大学生,按摄入益生菌的种类多少及菌落形成单位(CFU)高低,随机划分为五组;
  • 益生菌可改善恐慌焦虑、神经生理焦虑、负面情绪、忧虑状态,并促进负面情绪的调节;
  • 与益生菌的种类数量相比,CFU水平高低与焦虑症状缓解的关系更为密切,是益生菌发挥作用的主要因素;
  • 与正常一般症状相比,益生菌对严重焦虑参与者的改善效果更为明显;
  • 益生菌或可作为治疗焦虑的潜在治疗方法。
主编推荐语
周旸
《Journal of Affective Disorders》近期发表研究,纳入健康大学生作为研究对象,发现补充益生菌可以缓解焦虑、抑郁等不良情绪,该缓解作用对于益生菌剂量的依赖性大于益生菌种类。该结果对于研究脑肠轴、开发缓解情绪的调整手段具有参考价值。
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The Gut-Brain Relationship: Investigating the effect of multispecies probiotics on anxiety in a randomized placebo-controlled trial of healthy young adults

肠脑关系:一项随机安慰剂对照试验中多种益生菌对健康年轻人焦虑的影响

10.1016/j.jad.2019.04.043

2019-04-08, Article

Abstract & Authors:展开

Abstract:收起
Intro: There has been an increased interest in understanding the therapeutic effect of gut-microbiota on health, particularly in mental health. However, limited research into the connection between gut-microbiota and mental health makes this study an important endeavor in exploring the effect of gut-microbiota, through probiotics intervention, on mental health like anxiety and factors related to anxiety (e.g., anxiety control, affect, negative mood regulation, and worry).
Method: Healthy college students (N = 86; 75.6% female), average age of 20.59, participated in a double-blind, placebo-control, and randomization-control study. Eligible participants completed a baseline survey before being assigned to a condition, which consisted of four probiotics conditions and one placebo condition. After 28 days of daily intake, the participants returned to complete their exit survey.
Result: Probiotics were observed to improve panic anxiety, neurophysiological anxiety, negative affect, worry, and increase negative mood regulation. Furthermore, post hoc analyses revealed that the CFU (colony-forming unit) level was more effective than species counts in accounting for the number of significant improvements. A ceiling effect was detected in the study, participants with high distress reported higher number of improvements than those with normative distress.
Conclusion: Overall, this study is the first to examine the effect of CFU and species count on probiotics’ efficacy. The study's finding suggested that probiotics may have the therapeutic potential to treat anxiety, however, further research is necessary to make that determination.

First Authors:
Nhan Tran

Correspondence Authors:
Nhan Tran

All Authors:
Nhan Tran,Masha Zhebrak,Christine Yacoub,Joseph Pelletier,Darby Hawley

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