特定合生制剂可改善儿童发育不良
创作:吴芹 审核:周旸 2019年02月18日
  • 69名符合标准的2-5岁轻、中度轻度迟发性发育不良(FTT)的伊朗患儿分为合生制剂组和安慰剂组,其中37人摄入合生制剂(含多种乳杆菌、双歧杆菌和嗜热链球菌,以及低聚果糖);
  • 30天干预后,合生制剂组的平均体重及体重指数(BMI)增加显著高于安慰剂组;
  • 但在身高增加、感染次数、胃肠道问题及食欲改善上,两组间无显著差异;
  • 合生制剂能改善轻、中度FTT的伊朗儿童的体重和BMI情况,但参与者特征及地区差异等均会影响其作用。
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周旸
益生菌和益生元有优化胃肠道功能的潜在功能。本研究纳入伊朗的69名发育不良儿童,发现补充合生制剂可以改善体重和BMI指数,对缓解发育不良状况有一定的促进作用。
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The Effect of Synbiotic Supplementation on Growth Parameters in Mild to Moderate FTT Children Aged 2-5 Years

添加合生元对2-5岁轻、中度发育不良儿童生长参数的影响

10.1007/s12602-018-9508-6

2019-01-09, Article

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Synbiotic (probiotic bacteria and prebiotic) has beneficial effects on the gastrointestinal tract. This study was designed to investigate the effect of synbiotic supplementation on the growth of mild to moderate failure to thrive (FTT) children. A randomized, triple-blind, placebo-controlled trial was conducted involving 80 children aged 2-5 years with mild to moderate FTT, who were assigned at random to receive synbiotic supplementation (10 colony-forming units) or placebo for 30 days. The weights, height, and BMI were recorded in a structured diary, and the questionnaires were completed to monitor the numbers of infection episodes, gastrointestinal problems, admission to hospital, and appetite improvement during the study. Sixty-nine children completed the study. There were no differences in the demographic characteristic between the two groups. The mean weight was similar at baseline. After 30 days of intervention, the mean weight of the participants in the synbiotic group increased significantly than those in the placebo group (600 ± 37 vs. 74 ± 32 g/month P 0.000). BMI changes in synbiotic and placebo group were 0.44 and 0.07 kg/m, and that the differences among the two groups were significant.(P 0.045) Furthermore, the height increment in synbiotic and placebo group was 0.41 and 0.37 cm respectively with no significant difference (P 0.761). Administration of 30-day synbiotic supplementation may significantly improve weight and BMI in Iranian children with mild to moderate FTT, but there is no effect on the height in this study. Further studies should be designed to found out the effect of synbiotic on growth parameters in undernourished and well-nourished children.

First Authors:
Majid Aflatoonian,Abbas Taghavi Ardakani

Correspondence Authors:
Seyedeh Zalfa Modarresi

All Authors:
Majid Aflatoonian,Abbas Taghavi Ardakani,Seyedeh Zalfa Modarresi,Vajiheh Modaresi,Mehran Karimi,Mahtab Ordooei,Mahmood Vakili,Bahar Pakseresht

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