素食可能降低胆结石风险
创作:szx 审核:szx 2019年02月23日
  • 纳入4839名受试者,共进行29295人-年随访,随访期间发生104例胆结石;
  • 在校正年龄、教育程度、吸烟、饮酒、体育锻炼、糖尿病、肾病、BMI、降脂药使用及高胆固醇血症后,发现素食与女性的胆结石风险降低相关,但与男性的胆结石风险无显著关联;
  • 在女性中,有高胆固醇血症的非素食者的胆结石风险,是胆固醇水平正常的素食者的3.8倍;
  • 素食可能降低胆结石风险。
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szx
Nutrients上发表的一项前瞻性研究结果,在近5000名受试者中发现,素食与较低的胆结石风险相关。
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Nutrients [IF:4.546]

Plant-Based Diet, Cholesterol, and Risk of Gallstone Disease: A Prospective Study

素食、胆固醇与胆结石风险:一项前瞻性研究

10.3390/nu11020335

2019-02-04, Article

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Vegetarian diets may lower symptomatic gallstone disease via cholesterol lowering. This study aimed to examine the risk of symptomatic gallstone disease (GSD) in Taiwanese vegetarians vs. nonvegetarians in a prospective cohort and to explore if this association is related to cholesterol concentration. We prospectively followed 4839 participants, and in the 29,295 person-years of follow-up, 104 new incident GSD cases were confirmed. Diet was assessed through a validated food frequency questionnaire. Symptomatic GSD was ascertained through linkage to the Taiwan National Health Insurance Research Database. Blood cholesterol profiles were measured at recruitment. Cox regression was applied to assess the effect of diet on symptomatic GSD, adjusting for age, education, smoking, alcohol, physical activities, diabetes, kidney diseases, body mass index, lipid-lowering medication, and hypercholesterolemia. Vegetarian diet was associated with a decreased risk of symptomatic GSD compared with nonvegetarian diet in women (hazard ratio [HR], 0.52; 95% confidence interval [CI], 0.28–0.96) but not in men. In women, nonvegetarians with hypercholesterolemia had 3.8 times the risk of GSD compared with vegetarians with normal cholesterol (HR, 3.81, 95% CI, 1.61–9.01). A vegetarian diet may therefore protect against GSD independent of baseline hypercholesterolemia. A nonvegetarian diet and hypercholesterolemia may have an additive effect in increasing GSD risk in women.

First Authors:
Chun-Ming Chang

Correspondence Authors:
Chin-Lon Lin

All Authors:
Chun-Ming Chang,Tina H T Chiu,Chia-Chen Chang,Ming-Nan Lin,Chin-Lon Lin

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