四川大学等:中老年人的肠道菌群特征及其与免疫老化的关联
创作:女巫 审核:mildbreeze 2018年04月04日
  • 148例健康成年人分为中年组(50-59岁)和老年组(≥60岁);
  • 与年龄负相关的菌属:别样杆菌、(中年组)脱硫弧和栖粪杆菌、(老年组)毛杆菌和草酸杆菌;
  • 老年组中粪球菌属丰度显著升高,萨特氏菌属与年龄正相关;
  • 拟杆菌门(中年组)和Akk菌为代表的疣微菌门(老年组),与血清免疫球蛋白(两组分别对应IgG和IgA)水平和CD8+T细胞正相关、与CD4+/CD8+T细胞比值负相关;
  • 衰老过程中,肠道菌群组成改变和多样性下降,或与免疫老化相关。
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mildbreeze
四川大学华西公共卫生学院何方和李鸣团队主导的研究,分析了中国西南地区的148位健康中老年人的肠道菌群和血液免疫指标,鉴定出与年龄相关的菌属,表明衰老相关的特定菌群特征与免疫老化间可能存在关联。
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Gut Pathogens [IF:3.274]

Possible correlation between gut microbiota and immunity among healthy middle-aged and elderly people in southwest China

中国西南地区健康中老年人肠道菌群与免疫的相关性

10.1186/s13099-018-0231-3

2018-02-09, Article

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Background: The present study was conducted to investigate the possible association between gut microbes and immunity among healthy middle-aged and elderly individuals in southwest China. A total of 148 healthy adults aged ≥ 50 years were divided into two age groups: middle-aged group (50-59 years; n = 67, 54.13 ± 3.32) and elderly group (≥ 60 years; n = 81, 64.70 ± 3.93). Blood samples were collected to measure serum immune and biochemical indices. Gut microbiota compositions of the groups were characterized on the basis of faecal DNA using 16S rRNA gene sequencing.
Results: Among the detected gut microbes, the presence ofwas negatively correlated with age in both groups. In the middle-aged group, age was negatively correlated with the presence ofand. In the elderly group,was present at significantly higher levels; age was negatively correlated with the presence of,and the Chao index, whereas positively correlated with the presence ofIn the middle-aged group, the presence ofwas positively correlated with serum immunoglobulin G (IgG) levels and the percent of CD8T cells and negatively correlated with the CD4/CD8ratio; the presence ofwas negatively correlated with IgM levels;ratio was positively correlated with IgG and IgM levels and Simpson index was negatively correlated with the percent of CD8T cells and positively correlated with CD4/CD8ratio. In the elderly group, the presence of(identified as genus) was positively correlated with IgA levels and the percent of CD8T cells and negatively correlated with the percent of CD4T cells and CD4/CD8ratio; the Chao index and observed species were positively correlated with IgA levels.
Conclusions: These results indicated that ageing could significantly correlate with the composition of gut microbiota in terms of quantity and quality. Changes in gut microbiota caused by ageing, characterized by decreasedlevels, might be associated with immunosenescence among healthy middle-aged and elderly people in southwest China.

First Authors:
Xi Shen,Junjie Miao

Correspondence Authors:
Ming Li,Fang He

All Authors:
Xi Shen,Junjie Miao,Qun Wan,Shuyue Wang,Ming Li,Fangfang Pu,Guoqing Wang,Wei Qian,Qian Yu,Francesco Marotta,Fang He

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