Nature子刊:与早产相关的阴道菌群
创作:aluba 审核:aluba 2019年06月01日
  • 收集45名早产及90名足月产产妇的阴道样本,对16S rRNA、宏基因组、宏转录组及细胞因子谱进行纵向分析;
  • 早产产妇的阴道菌群多样性增加,卷曲乳杆菌的丰度降低,细菌性阴道炎相关细菌1(BVAB1)、TM7-H1等13个分类群的丰度增加;
  • 基于4种早产相关分类群(收集于孕期24周或更早)构建早产预测模型,灵敏度和特异性分别为77.4%及76.3%;
  • 早产相关分类群与阴道分泌物中的促炎细胞因子水平显著相关;
  • 首次报道了BVAB1及TM7-H1的基因组。
主编推荐语
aluba
Nature Medicine上发布的一项来自整合人体微生物组计划(iHMP)的研究成果,报道了1572名孕妇的阴道菌群多组学数据,同时对45名早产产妇及90名足月产产妇的多组学数据进行了对比,鉴定出了与早产相关的阴道菌群分类群,这些分类群可较好地预测早产风险,提示阴道菌群或可用于未来的早产风险评估。
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Nature Medicine [IF:53.44]

The vaginal microbiome and preterm birth

阴道菌群与早产

10.1038/s41591-019-0450-2

2019-05-29, Article

Abstract & Authors:展开

Abstract:收起
The incidence of preterm birth exceeds 10% worldwide. There are significant disparities in the frequency of preterm birth among populations within countries, and women of African ancestry disproportionately bear the burden of risk in the United States. In the present study, we report a community resource that includes ‘omics’ data from approximately 12,000 samples as part of the integrative Human Microbiome Project. Longitudinal analyses of 16S ribosomal RNA, metagenomic, metatranscriptomic and cytokine profiles from 45 preterm and 90 term birth controls identified harbingers of preterm birth in this cohort of women predominantly of African ancestry. Women who delivered preterm exhibited significantly lower vaginal levels of Lactobacillus crispatus and higher levels of BVAB1, Sneathia amnii, TM7-H1, a group of Prevotella species and nine additional taxa. The first representative genomes of BVAB1 and TM7-H1 are described. Preterm-birth-associated taxa were correlated with proinflammatory cytokines in vaginal fluid. These findings highlight new opportunities for assessment of the risk of preterm birth.

First Authors:
Jennifer M Fettweis

Correspondence Authors:
Gregory A Buck

All Authors:
Jennifer M Fettweis,Myrna G Serrano,J Paul Brooks,David J Edwards,Philippe H Girerd,Hardik I Parikh,Bernice Huang,Tom J Arodz,Laahirie Edupuganti,Abigail L Glascock,Jie Xu,Nicole R Jimenez,Stephany C Vivadelli,Stephen S Fong,Nihar U Sheth,Sophonie Jean,Vladimir Lee,Yahya A Bokhari,Ana M Lara,Shreni D Mistry,Robert A Duckworth III,Steven P Bradley,Vishal N Koparde,X Valentine Orenda,Sarah H Milton,Sarah K Rozycki,Andrey V Matveyev,Michelle L Wright,Snehalata V Huzurbazar,Eugenie M Jackson,Ekaterina Smirnova,Jonas Korlach,Yu-Chih Tsai,Molly R Dickinson,Jamie L Brooks,Jennifer I Drake,Donald O Chaffin,Amber L Sexton,Michael G Gravett,Craig E Rubens,N Romesh Wijesooriya,Karen D Hendricks-Muñoz,Kimberly K Jefferson,Jerome F Strauss III,Gregory A Buck

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iHMP 第二弹 | 阴道微生物与早产

菌探Momics,2019-06-18

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