青春期吃太多糖,成年后可能记性不好?
创作:楸楸 审核:szx 04月11日
  • 大鼠青春期发育阶段摄入含糖饮料,可损伤成年后的海马依赖性记忆功能,而不影响体重或焦虑状行为;
  • 含糖饮料改变肠道菌群,包括与海马功能呈负相关的两种副拟杆菌属物种(狄氏副拟杆菌和约氏副拟杆菌)丰度增加;
  • 大鼠青春期移植上述特定细菌分类群,可损伤成年后的海马依赖性记忆;
  • 糖摄入改变细胞内激酶和突触神经递质信号通路中的基因表达,而副拟杆菌属富集改变与代谢功能、神经退行性疾病和多巴胺能信号相关通路中的基因表达。
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szx
生命早期摄入过多的糖可能影响肠道菌群,并损伤神经认知。Translational Psychiatry上发表的一项最新研究,发现青春期摄入过多的含糖饮料,可通过改变肠道菌群组成(使特定副拟杆菌物种富集)及功能,从而损伤大鼠成年后的记忆功能。
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Gut microbial taxa elevated by dietary sugar disrupt memory function

膳食糖摄入增加的肠道菌群分类群可破坏记忆功能

10.1038/s41398-021-01309-7

03-31, Article

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Emerging evidence highlights a critical relationship between gut microbiota and neurocognitive development. Excessive consumption of sugar and other unhealthy dietary factors during early life developmental periods yields changes in the gut microbiome as well as neurocognitive impairments. However, it is unclear whether these two outcomes are functionally connected. Here we explore whether excessive early life consumption of added sugars negatively impacts memory function via the gut microbiome. Rats were given free access to a sugar-sweetened beverage (SSB) during the adolescent stage of development. Memory function and anxiety-like behavior were assessed during adulthood and gut bacterial and brain transcriptome analyses were conducted. Taxa-specific microbial enrichment experiments examined the functional relationship between sugar-induced microbiome changes and neurocognitive and brain transcriptome outcomes. Chronic early life sugar consumption impaired adult hippocampal-dependent memory function without affecting body weight or anxiety-like behavior. Adolescent SSB consumption during adolescence also altered the gut microbiome, including elevated abundance of two species in the genus Parabacteroides (P. distasonis and P. johnsonii) that were negatively correlated with hippocampal function. Transferred enrichment of these specific bacterial taxa in adolescent rats impaired hippocampal-dependent memory during adulthood. Hippocampus transcriptome analyses revealed that early life sugar consumption altered gene expression in intracellular kinase and synaptic neurotransmitter signaling pathways, whereas Parabacteroides microbial enrichment altered gene expression in pathways associated with metabolic function, neurodegenerative disease, and dopaminergic signaling. Collectively these results identify a role for microbiota “dysbiosis” in mediating the detrimental effects of early life unhealthy dietary factors on hippocampal-dependent memory function.

First Authors:
Emily E Noble

Correspondence Authors:
Elaine Hsiao,Scott E Kanoski

All Authors:
Emily E Noble,Christine A Olson,Elizabeth Davis,Linda Tsan,Yen-Wei Chen,Ruth Schade,Clarissa Liu,Andrea Suarez,Roshonda B Jones,Claire de La Serre,Xia Yang,Elaine Hsiao,Scott E Kanoski

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Medical Xpress新闻网站

Sugar not so nice for your child's brain development

2021-03-31

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